Thiol-Disulfide Homeostasis and Ischemia Modified Albumin as a New Oxidative Stress Marker in Patients with Polycythemia Vera
Huseyin Erdal1, Rafiye Ciftciler2, Sibel Cigdem Tuncer3, Oguzhan Ozcan41Department of Medical Genetics, Faculty of Medicine, Aksaray University, Aksaray, Türkiye, 2Department of Hematology, Faculty of Medicine, Selcuk University, Konya, Türkiye Department of Hematology, Faculty of Medicine, Selcuk University, Konya, Türkiye, 3Deparment of Biochemistry, Faculty of Medicine, Aksaray University, Aksaray, Türkiye, 4Department of Biochemistry, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Türkiye
Objectives: The present study aims to indicate both thiol-disulfide hemostasis and ischemia-modified albumin (IMA) levels in patients with Polycythemia Vera (PV). Methods: In this prospective case-control study, 34 PV patients and 31 healthy control participants were included. Thiol levels were measured with a new modified colorimetric method. IMA levels were determined by cobalt binding test. Results: Thiol levels were statistically significant between the groups. (p<0.001). IMA levels were also significanlty higher in PV group than healthy control subjects (p<0.001). We revealed that thiol and IMA levels were significantly higher in patients with PV in respect to the control groups. Conclusion: The obtain results indicate that the oxidative balance is disturbed and changed towards the oxidant direction. The dynamic- thiol disulfide balance has moved to proliferation side in patients with PV, and may provide important contributions to the patient's follow-up and disease pathophysiology. Keywords: Free radical, polycythemia vera, thiol-disulfide homeostasis, total antioxidant status, total oxidant status, ischemia -modified albumin
Cite This Article
Erdal H, Ciftciler R, Tuncer S, Ozcan O. Thiol-Disulfide Homeostasis and Ischemia Modified Albumin as a New Oxidative Stress Marker in Patients with Polycythemia Vera. EJMI. 2023; 7(4): 466-470
Corresponding Author: Huseyin Erdal