In Vitro Study of Thymohydroquinone and Dithymoquinone from Nigela Sativia Targeting SARS-CoV2
Hanuman Singh Dagur1, Neeharika Singh21Department of Biotechnology, Jaipur National University, Jaipur, India., 2Department of Biotechnology, Indian Institute of Technology, Hyderabad, Telangana, India
This article has been retracted by the editorial board due to plagiarism.
This article has been retracted by the editorial board due to plagiarism.
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Objectives: Inflammation, oxidation, and compromised immunity all increase the dangers of COVID-19, whereas many
pharmaceutical protocols may lead to increased immunity such as ingesting from sources containing vitamin E and
zinc. A global search for natural remedies to fight COVID-19 has emerged, to assist in the treatment of this infamous
coronavirus. Nigella satvia is a world- renowned plant, an esteemed herbal remedy, which can be used as a liquid medicine to increase immunity while decreasing the dangers of acute respiratory distress syndrome. Thymoqinone (TQ),
dithemoqunone (DTQ) and thymohydroquinon (THQ), are major compounds of the essential oil contained in N.sativa.
Methods: A current study aims to discover the antiviral activity of two compounds, Thymohydroquinone and Dithymoquinone, which are synthesized through simple chemical procedures, deriving from thymoquinone, which happens to
be a major compound of Nigella sativa. A half maximal cytotoxic concentration, “CC50”, was calculated by MTT assay
for each individual drug.
Results: The sample showed anti-SARS-CoV-2 activity at non-cytotoxic nanomolar concentrations in vitro with a low
selectivity index (CC50/IC50 = 31.74/23.15=1.4), whereby Dimthymoquinone shows high cytotoxicity.
Conclusion: Thymohydroquinone and Dithymoquinone showed anti-SARS CoV-2 activity and further can be used to
treat covid-19.
Keywords: Thymohydroquinone, Dithymoquinone, SARS-CoV-2.
Cite This Article
Dagur H, Singh N. In Vitro Study of Thymohydroquinone and Dithymoquinone from Nigela Sativia Targeting SARS-CoV2. EJMI. 2022; 6(1): 111-121
Corresponding Author: Hanuman Singh Dagur