Clinical Features and Survival Outcomes in Primary Intestinal Lymphoma: A Multicenter Retrospective Study
Merve Turan11Department of Medical Oncology, Aydın Adnan Menderes University Faculty of Medicine, Aydın, Türkiye
Objectives: Primary intestinal lymphoma (PIL) is a rare, heterogeneous extranodal malignancy, and data on its clinical course and survival in routine practice are scarce. We evaluated the clinical features, treatment patterns, and survival outcomes of patients with PIL in a multicenter cohort. Methods: This multicenter retrospective study included 68 patients diagnosed with PIL between 2000 and 2013 at five tertiary oncology centers in Türkiye. Clinical, pathological, and treatment-related variables were collected from medical records. Overall survival (OS) and progression-free survival (PFS) were estimated by the Kaplan–Meier method and compared with the log-rank test; hazard ratios (HRs) were estimated with Cox regression limited to two covariates per model because of the small number of events. Results: The median age was 45 years, and diffuse large B-cell lymphoma was the most common subtype. Most patients presented with early-stage disease. Over a median follow-up of 53 months, estimated 2-year PFS and OS were 61% (95% CI: 44–71%) and 66% (95% CI: 51–78%), respectively, and median OS was not reached. On univariate analysis, advanced stage, poor ECOG performance status, higher IPI score, and lack of treatment response were significantly associated with worse survival. ECOG performance status 3–4 remained associated with inferior OS after adjustment for stage (HR 8.80, 95% CI: 3.12–24.86). Surgery was associated with longer PFS in the log-rank analysis, but not in Cox regression, and no significant OS benefit was observed. Conclusion: In this multicenter cohort, PIL survival was associated with established clinical risk factors. Because the number of events was small and most analyses were univariate, these findings should be regarded as exploratory realworld observations. Keywords: Extranodal non-Hodgkin lymphoma, multicenter study, primary intestinal lymphoma, real-world data, survival outcomes
Cite This Article
Turan M. Clinical Features and Survival Outcomes in Primary Intestinal Lymphoma: A Multicenter Retrospective Study. EJMI. 2026; 10(4): 646-655
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