Investigation of Factors Predicting Disease Recurrence and Survival in Triple-Negative Breast Cancer Patients
Aysun Fatma Akkuş1, Osman Köstek2, Muhammet Bekir Hacioglu1, Bülent Erdogan1, Irfan Çiçin3, Sernaz Topaloğlu11Department of Medical Oncology, Trakya University Faculty of Medicine, Edirne, Türkiye, 2Department of Medical Oncology, Marmara University Faculty of Medicine, Istanbul, Türkiye, 3Department of Medical Oncology, İstinye University Faculty of Medicine, Istanbul, Türkiye
Objectives: This retrospective study aimed to identify factors influencing disease recurrence and survival in patients with triple-negative breast cancer (TNBC). Methods: The study included 69 patients who were admitted to the medical oncology clinic of Trakya University between January 1, 2012, and March 1, 2019. Clinicopathological characteristics, recurrence, survival factors, and treatment approaches were evaluated. Univariate and multivariate analyses were performed. Data were expressed as mean±SD, with comparisons made using the independent t-test for parametric variables and Chi-square test for nonparametric variables. Survival was analyzed using Kaplan-Meier and Cox regression, with a significance level of p<0.05. Results: Of the 69 patients, 11 received neoadjuvant therapy, and 58 received adjuvant therapy. The median diseasefree survival was 50.2 months, and the median overall survival was 123.1 months. Disease-free survival was shorter in patients with Ki-67 >30% (p=0.006). Advanced age (>60 years) and neoadjuvant therapy were independent predictors of disease-free survival, with overall survival being lower in patients over 60. Conclusion: Genetic counseling for BRCA mutation testing is recommended for this patient group. No significant findings were observed for other clinical and demographic factors. Due to the retrospective nature and small sample size, further studies with larger patient groups are needed. Keywords: Triple negative breast cancer, overall survival, disease-free survival
Cite This Article
Akkuş A, Köstek O, Hacioglu M, Erdogan B, Çiçin I, Topaloğlu S. Investigation of Factors Predicting Disease Recurrence and Survival in Triple-Negative Breast Cancer Patients. EJMI. 2025; 9(3): 152-160
Corresponding Author: Aysun Fatma Akkuş