The Prognostic Importance of Clinicopathological Factors in Patients with Osteosarcoma Who Received Neoadjuvant Therapy; A Single Center Experience
Fatih Simsek1, Nargiz Majidova1, Muhammed Fatih Kırcali1, Nadiye Sever1, Abdussamet Celebi1, Rukiye Arikan1, Osman Kostek11Division of Medical Oncology, Department of Internal Medicine, Marmara University Faculty of Medicine, İstanbul, Türkiye
Objectives: Osteosarcoma has worse prognosis in adult patients but cure is possible even in the metastatic stage. Survival rates have been significantly improved with systemic chemotherapy. We aimed to investigate the effects of clinicopathological factors on overall-survival (OS) and disease-free-survival (DFS) in 77osteosarcoma who received neoadjuvant treatment and were treated in our center. Methods: The patients were 18 years of age and over, applied to the Marmara University of Medical Oncology outpa tient clinic between 2001-2022. Results: The overall 5-year DFS rate is 35.5%. Patients with primary tumor location in the pelvis had 5-year DFS rate of 20.0%, whereas patients with a primary location outside the pelvis had a DFS rate of 36.6%. After neoadjuvant therapy, patients with a necrosis rate of 90% or more had a 5-year DFS rate of 54.0%, while patients with a necrosis rate of less than 90% had rate of 31.6%. Conclusion: Significant prognostic indicators for DFS were found to be female gender, primary pelvic location, and completion of adjuvant therapy in patients who underwent surgery after neoadjuvant therapy. The completion of adjuvant chemotherapy in patients who underwent surgery after neoadjuvant therapy and a necrosis rate of 90% or more in the pathology report were discovered to be significant prognostic markers for OS. Keywords: Disease-free survival, neoadjuvant, osteosarcoma, overall survival
Cite This Article
Simsek F, Majidova N, Kırcali M, Sever N, Celebi A, Arikan R, Kostek O. The Prognostic Importance of Clinicopathological Factors in Patients with Osteosarcoma Who Received Neoadjuvant Therapy; A Single Center Experience. EJMI. 2024; 8(3): 184-192
Corresponding Author: Osman Kostek