E-ISSN 2602-3164
EJMI. 2024; 8(4): 226-232 | DOI: 10.14744/ejmi.2024.76627

Prognostic Importance of Cyclooxygenase-2 Expression and Its Relationship with Histology in Non-Hodgkin's Lymphomas

Mehmet Gökhan Gönenli1, Yavuz Burak Tor2, Burçin Saglam1, Bahar Tekin Cetin1, Faysal Dane3
1Department of Internal Medicine, Koc University, Faculty of Medicine, Istanbul, Türkiye, 2Department of Internal Medicine, Memorial Bahcelievler Hospital, Istanbul, Türkiye, 3Department of Medical Oncology, Acibadem Altunizade Hospital, Istanbul, Türkiye

Objectives: The presence and prognostic relevance of cyclooxygenase-2 (COX-2) expression have been explored in various neoplasms, but its role in non-Hodgkin's lymphomas (NHLs) is poorly understood. This study aims to reveal the clinicopathologic and prognostic importance of COX-2 expression in NHLs. Methods: Diagnostic tissue samples from 66 NHL patients were immunohistochemically stained to assess COX-2 expression, with a final cohort of 64 patients. Clinicopathological parameters were compared between COX-2 positive and negative groups. Results: From a histological perspective, the indolent group comprised 21 patients (32.8%), while the aggressive group included 43 patients (67.2%). The samples of 26 patients (40.6%) were COX-2 positive and 38 (59.4%) were COX-2 negative. A significant relationship was observed between IHS scores and lymphoma aggressiveness (p=0.044), indicating a connection between COX-2 overexpression and aggressive histology. Response to treatment rate was 89.5% in COX-2 negative group and 73.1% in COX-2 positive group (p=0.088). The overall survival (OS) was 31.81 months for the COX-2 positive group and 34.87 months for the COX-2 negative group, with no statistically significant difference (p=0.581). Conclusion: COX-2 overexpression is significantly associated with aggressive histology in NHLs. However, its impact on OS and treatment response needs further investigation with larger sample size. Keywords: Cyclooxygenase-2, expression, non-Hodgkin lymphoma, prognosis


Cite This Article

Gönenli M, Tor Y, Saglam B, Cetin B, Dane F. Prognostic Importance of Cyclooxygenase-2 Expression and Its Relationship with Histology in Non-Hodgkin's Lymphomas. EJMI. 2024; 8(4): 226-232

Corresponding Author: Yavuz Burak Tor

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