Renal Protective Effect of Dexpanthenol on Doxorubicin Induced Nephrotoxicity: An Experimental Rat Study
Hakan Turk1, Erkan Arslan1, Mehmet Abdulkadir Sevuk2, Muhammed Erdogan3, Serife Tasan41Department of Urology, Usak University, Faculty of Medicine, Usak, Türkiye, 2Department of Pharmacology, Suleyman Demirel University, Faculty of Medicine, Isparta, Türkiye, 3Department of Biochemistry, Suleyman Demirel University, Faculty of Medicine, Isparta, Türkiye, 4Department of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Türkiye
Objectives: It is a condition in which kidney damage occurs in patients receiving doxorubicin treatment and prevents the continuation of treatment. In this study, we aimed to demonstrate the preventive effect of dexpanthenol on kidney damage in rats given doxorubicin experimentally. Methods: Thirty-two male rats (weight 250-300 g) were randomly divided into 4 groups, with 8 in each group. The con trol group was given 0.8 ml saline instead of doxorubicin. 2.5 mg/kg doxorubicin was given to the doxorubicin group cumulative dose of 15 mg/kg. In the doxorubicin + dexpanthenol group, 500 mg/kg dexpanthenol was applied to the left inguinal regions of the rats as i.p. every day for 14 days, and 15 mg/kg doxorubicin was applied. Results: Kidney damage was significantly less in the group receiving dex compared to the group receiving only dox (p<0.05). Dexpanthenol showed this effect by reducing oxidative stress, especially Cas-3 and TNF-a values (p<0.05). Conclusion: It has been shown in many studies that dexpanthenol has a protective effect against oxidative stress. How ever, its effect against real damage due to doxorubicin has not been studied before. Our study is important as it shows that doxorubicin-related kidney damage can be reduced with dexpanthenol. Keywords: Dexpanthenol, doxorubicin, inflammation, nephrotoxicity, oxidative stress
Cite This Article
Turk H, Arslan E, Sevuk M, Erdogan M, Tasan S. Renal Protective Effect of Dexpanthenol on Doxorubicin Induced Nephrotoxicity: An Experimental Rat Study. EJMI. 2024; 8(3): 193-199
Corresponding Author: Hakan Turk