Effect of Maintenance anti-EGFR Therapy on Survival in Metastatic RAS Wild-Type Colorectal Cancer: Single-Center Experience
Serdar Ileri1, Ogur Karhan1, Yasin Sezgin1, Sezai Tunc1, Ziya Kalkan1, Halis Yerlikaya11Department of Medical Oncology, Dicle University Faculty of Medicine, Diyarbakir, Türkiye
Objectives: The combination of anti-EGFR agents with chemotherapy is used in the first-line treatment of metastatic colorectal cancer (mCRC). The aim of this study is to evaluate the efficacy of anti-EGFR maintenance therapy in patients with metastatic RAS wild-type left colon. Methods: In this retrospective, single-center study, 273 patients with mCRC who were treated at Dicle University Medical Oncology Clinic between December 2014 and March 2021 were reviewed. Patients were analyzed for progressionfree survival (PFS) and overall survival (OS). Results: Data obtained from 35 patients. Regarding maintenance chemotherapy agents, 14 (40%) received FOLFIRI, 16 (45.7%) received 5-FU, and the remaining received other agents. Among the patients, 21 (60%) received cetuximab as anti-EGFR therapy and 14 (40%) received panitumumab. The median follow-up was 30 months (8-73). Median PFS was 22 months (16.8-27.1) who received cetuximab and 14 months (10.8-17.1) who received panitumumab (p=0.1). Median PFS was 15 months (10.6-19.3) for receiving FOLFIRI and 22 months (17.2-26.7) for receiving 5-FU (p=0.058). Median OS was 25 months (8.1-41.8) for receiving FOLFIRI and 54 months (31.5-76.4) for receiving 5-FU (p=0.059). Conclusion: Our study showed that maintenance therapy with cetuximab and panitumumab had comparable efficacy. 5-FU showed borderline statistical significance in terms of efficacy compared to FOLFIRI. Keywords: Cetuximab, panitumumab, maintenance therapy, metastatic colorectal cancer
Cite This Article
Ileri S, Karhan O, Sezgin Y, Tunc S, Kalkan Z, Yerlikaya H. Effect of Maintenance anti-EGFR Therapy on Survival in Metastatic RAS Wild-Type Colorectal Cancer: Single-Center Experience. EJMI. 2024; 8(4): 280-285
Corresponding Author: Serdar Ileri