The Effect of Neutrophil/High-Density Lipoprotein Cholesterol Ratio on Survival in Patients on Maintenance Hemodialysis
Sinan Kazan1, Elif Dizen Kazan2, Onur Tunca11Department of Nephrology, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Türkiye, 2Department of Internal Medicine, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Türkiye
Objectives: In this study, we aimed to investigate the effect of neutrophil/high-density lipoprotein cholesterol (HDL-C) ratio on survival in patients receiving maintenance hemodialysis treatment. Methods: The files of all patients who received maintenance hemodialysis treatment as renal replacement therapy in our hospital for more than 3 months between January 1, 2016, and January 1, 2022, were retrospectively scanned (n=241). The neutrophil/ HDL-C ratio was calculated by dividing the final absolute neutrophil count by HDL-C. Results: The study was conducted with 207 maintenance hemodialysis patients. The median age of the study group was 60 years (Q1-Q3=52–66 years). The median dialysis duration of patients was 37 months (Q1-Q3=17–45 months). It was determined that 22.7% (n=47) of the patients died during their follow-up. The median neutrophil/ HDL-C ratio was significantly higher in deceased patients than in survivors (197 vs. 123.5, p<0.001). The neutrophil/ HDL-C ratio value that best discriminated between deceased and surviving patients was found to be 146.1 with 95.7% sensitivity and 67.5% specificity (AUC=0.855, 95% CI=0.804–0.906, p<0.001). Kaplan–Meier curves revealed that the all-cause mortality rate was significantly higher in the high neutrophil/ HDL-C ratio group than in the low neutrophil/ HDL-C ratio group (log-rank p<0.001). Conclusion: It was found that mortality was significantly increased in maintenance hemodialysis patients with a higher neutrophil/HDL-C ratio. In addition, the neutrophil/HDL-C ratio appears to be an independent risk factor for mortality in maintenance hemodialysis patients. Keywords: Dialysis, high-density lipoprotein, mortality, neutrophils
Cite This Article
Kazan S, Dizen Kazan E, Tunca O. The Effect of Neutrophil/High-Density Lipoprotein Cholesterol Ratio on Survival in Patients on Maintenance Hemodialysis. EJMI. 2023; 7(1): 88-93
Corresponding Author: Sinan Kazan