Novel Diagnostic Parameters in the Differentiation of Isolated Iron Deficiency and Iron Deficiency Accompanying Chronic Disease before Progressing Anemia
Muzaffer Serdar Deniz1, Selma Karaahmetoglu21Department of Endocrinology, Karabük University, Faculty of Medicine, Training and Research Hospital, Karabük, Türkiye, 2Department of Internal Medicine, Ankara City Hospital, Health of Ministry, Bilkent, Ankara, Türkiye
Objectives: The study aimed to investigate the patients with isolated iron deficiency (IID) and chronic disease-accompanied iron deficiency (CDID) and to analyze the predictive values of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) that can help us to distinguish IID from CDID. Methods: Three hundred patients joined the present cross-sectional thesis study. Half had chronic diseases+ID (without anemia) called as CDID, while the other half did not have any chronic disease or anemia called IID in the text. Laboratory parameters and patient histories were obtained from the automation system and analyzed. Results: The CDID was associated with ferritin increase (Odds Ratio [OR]=1.123; 95% Confidence Intervals [CI]=1.084– 1.165). Increased sedimentation was associated with an increased risk of having a CDID (OR=1.023; 95% CI = 1.003– 1.045). Ferritin showed a predictive potential for CDID with 67.2% specificity and 71.1% sensitivity at a 12.1 cutoff value (Auc:0.781; p<0.0001). NLR was the second strong predictor of CDID against IID, with 64.1% specificity and 63.5% sensitivity at a 2.09 cutoff (Auc:0.629; p<0.0001). PLR had no significance for discrimination of CDID and IID. Conclusion: NLR can provide diagnostic support like ferritin in predicting CDID against IID and benefit physicians in the clinical use of differentiation, unlike PLR. Keywords: Iron deficiency, neutrophil lymphocyte ratio, platelet lymphocyte ratio
Cite This Article
Deniz M, Karaahmetoglu S. Novel Diagnostic Parameters in the Differentiation of Isolated Iron Deficiency and Iron Deficiency Accompanying Chronic Disease before Progressing Anemia. EJMI. 2023; 7(2): 141-145
Corresponding Author: Muzaffer Serdar Deniz