EJMI. 2023; 7(2): 94-100 | DOI: 10.14744/ejmi.2023.90882

Vitamin D Efficacy on Prognosis of Bladder Cancer Patients

Canan Karan¹, Arzu Yaren², Burcin Cakan Demirel², Tolga Dogan², Melek Ozdemir², Atike Gokcen Demiray², Burcu Yapar Taskoylu², Serkan Degirmencioglu², Gamze Dogu², Nail Ozhan³, Umut Cakiroglu^4
1Department of Medical Oncology, Dr. Ersin Aslan Trainig and Research Hospital, Gaziantep, Türkiye, ²Department of Medical Oncology, Pamukkale University, Faculty of Medicine, Denizli, Türkiye, ³Department of Medical Oncology, Egekent Hospital, Denizli, Türkiye, ⁴Department of Medical Oncology, Van Trainig and Research Hospital, Van, Türkiye

Objectives: This study aimed to investigate the predictive value of vitamin D levels in patients with bladder cancer before systemic treatment. Methods: A total of 125 bladder cancer patients were included in the study. The Kaplan–Meier method was used to estimate overall survival (OS) and progression-free survival (PFS), and the long-rank test was used for comparison. Univariate and multivariate Cox proportional hazards models were used to determine the association vitamin D and OS. Results: The measured PFS and OS of the patients were 260.7 weeks and 323.6 weeks, respectively. Receiver operating characteristic analysis revealed that vitamin D level <12.5 ng/dl was determined as the optimal cutoff value for OS prediction with the sensitivity of 62.5% and specificity of 58.5% (AUC:0.633, p=0.01). After adjustment for the number of covariates, multivariate Cox regression analysis identified a lower vitamin D level as an independent predictive factor of worse OS (hazard ratio: 2.774, 95% confidence interval: 1.486–5.178, p=0.001). Conclusion: Our results suggested that vitamin D level might function as an independent predictor in patients with bladder cancer before systemic treatment. Keywords: Bladder cancer, overall survival, prognostic factors, progression-free survival, vitamin D level

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Cite This Article

Karan C, Yaren A, Cakan Demirel B, Dogan T, Ozdemir M, Gokcen Demiray A, Yapar Taskoylu B, Degirmencioglu S, Dogu G, Ozhan N, Cakiroglu U. Vitamin D Efficacy on Prognosis of Bladder Cancer Patients. EJMI. 2023; 7(2): 94-100

Corresponding Author: Canan Karan

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