E-ISSN 2602-3164
EJMI. 2023; 7(2): 94-100 | DOI: 10.14744/ejmi.2023.90882

Vitamin D Efficacy on Prognosis of Bladder Cancer Patients

Canan Karan1, Arzu Yaren2, Burcin Cakan Demirel2, Tolga Dogan2, Melek Ozdemir2, Atike Gokcen Demiray2, Burcu Yapar Taskoylu2, Serkan Degirmencioglu2, Gamze Dogu2, Nail Ozhan3, Umut Cakiroglu4
1Department of Medical Oncology, Dr. Ersin Aslan Trainig and Research Hospital, Gaziantep, Türkiye, 2Department of Medical Oncology, Pamukkale University, Faculty of Medicine, Denizli, Türkiye, 3Department of Medical Oncology, Egekent Hospital, Denizli, Türkiye, 4Department of Medical Oncology, Van Trainig and Research Hospital, Van, Türkiye

Objectives: This study aimed to investigate the predictive value of vitamin D levels in patients with bladder cancer before systemic treatment. Methods: A total of 125 bladder cancer patients were included in the study. The Kaplan–Meier method was used to estimate overall survival (OS) and progression-free survival (PFS), and the long-rank test was used for comparison. Univariate and multivariate Cox proportional hazards models were used to determine the association vitamin D and OS. Results: The measured PFS and OS of the patients were 260.7 weeks and 323.6 weeks, respectively. Receiver operating characteristic analysis revealed that vitamin D level <12.5 ng/dl was determined as the optimal cutoff value for OS prediction with the sensitivity of 62.5% and specificity of 58.5% (AUC:0.633, p=0.01). After adjustment for the number of covariates, multivariate Cox regression analysis identified a lower vitamin D level as an independent predictive factor of worse OS (hazard ratio: 2.774, 95% confidence interval: 1.486–5.178, p=0.001). Conclusion: Our results suggested that vitamin D level might function as an independent predictor in patients with bladder cancer before systemic treatment. Keywords: Bladder cancer, overall survival, prognostic factors, progression-free survival, vitamin D level

Cite This Article

Karan C, Yaren A, Cakan Demirel B, Dogan T, Ozdemir M, Gokcen Demiray A, Yapar Taskoylu B, Degirmencioglu S, Dogu G, Ozhan N, Cakiroglu U. Vitamin D Efficacy on Prognosis of Bladder Cancer Patients. EJMI. 2023; 7(2): 94-100

Corresponding Author: Canan Karan

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