Chemotherapy Timing During Visceral Crisis in Patients with Liver Metastatic Solid Carcinoma
Mustafa Buyukkor11Department of Medical Oncology, Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Türkiye
Objectives: The aim of the study is to investigate the impact of the timing of chemotherapy (CT) initiation and CT protocol on overall survival (OS) in patients with hepatic visceral crisis (HVC). Methods: The study evaluated the timing of starting CT and the contribution of the initiated CT protocol to OS in patients with hepatic visceral crisis (HVC) who have clinical symptoms due to tumor burden characterized by liver metastasis and hyperbilirubinemia ?1.5 times the upper limit, along with elevated at least one of ALT/AST values. Results: Between November 2007 and July 2021, analyzed 233 patients in HVC. 60 individuals were able to receive CT and divided into two groups based on the timing of initiating CT during HVC. CT initiated patients within 7 days were observed to have longer median OS (mOS) compared to patients initiated CT after 7 days (3.88 vs 2.99 months; p=0.04). Furthermore single-agent CT exhibited a significantly mOS compared to patients unable to undergo CT (1.70 months vs 1.08 months; p=0.03) Additionally patients who received combination CT had longer mOS compared to those who received monotherapy (4.27 months vs 1.70 months; p=0.03). Conclusion: Initiating early CT during HVC in eligible patients has a positive impact on OS. Keywords: Chemoterapy, liver dysfunction, metastasis, survival, visceral crisis
Cite This Article
Buyukkor M. Chemotherapy Timing During Visceral Crisis in Patients with Liver Metastatic Solid Carcinoma. EJMI. 2023; 7(4): 447-453
Corresponding Author: Mustafa Buyukkor