The Relationship Between Chemotherapy Related Neutropenia and Survival in Ovarian Cancer
Elif Atag1, Behzat Can2, Baran Akagunduz3, Muzaffer Sanci4, Huseyin Salih Semiz11Department of Medical Oncology, Dokuz Eylül University Institute of Oncology, Izmir, Türkiye, 2Department of Gynecological Oncology, Kahramanmaraş Necip Fazıl City Hospital, Kahramanmaraş, Türkiye, 3Department of Medical Oncology, Erzincan Binali Yildirim University Mengücek Gazi Training and Research Hospital, Erzincan, Türkiye, 4Department of Gynecological Oncology, Health Science University, Tepecik Training and Research Hospital, İzmir, Türkiye
Objectives: Due to limited data in the literature, we aimed to determine the relationship between the development of chemotherapy-induced neutropenia and survival in patients with ovarian cancer who underwent frontline cytoreductive surgery and received adjuvant chemotherapy. Methods: In this study, laboratory parameters in the hospital database were collected retrospectively. The rates of patients who developed neutropenia due to chemotherapy and the relationship between neutropenia and survival were analyzed using appropriate statistical methods. Results: A total of 82 patients were included in the study. The median age was 53.3 years. Median follow-up time was 61,6 months. Median chemotherapy cycles were 6. Disease recurrence developed in 22 (26.8%) patients and 12 patients (14.6%) were died during the follow-up period. Any degree of neutropenia developed in a total of 63 (76.8%) patients during the entire chemotherapy period. There were no grade 4 neutropenia. No correlation was found between the development of neutropenia and disease free survival or overall survial. Conclusion: There are conflicting data in the literature regarding the relationship between chemotherapy-induced neutropenia and survival in patients with ovarian cancer who are receiving adjuvant chemotherapy. In our study, no relationship was found between the development of neutropenia and survival. Keywords: Chemotherapy, ovarian cancer, neutropenia
Cite This Article
Atag E, Can B, Akagunduz B, Sanci M, Semiz H. The Relationship Between Chemotherapy Related Neutropenia and Survival in Ovarian Cancer. EJMI. 2023; 7(1): 58-62
Corresponding Author: Huseyin Salih Semiz