EJMI. 2023; 7(2): 175-180 | DOI: 10.14744/ejmi.2023.72707

Does Mammographic Density Predict Pathological Complete Response in Patients with Locally Advanced Breast Cancer Receiving Neoadjuvant Chemotherapy?

Mehmet Uzun¹, Elif Kurtulus², Eda Caliskan Yildirim¹, Ilkay Tuba Unek¹, Huseyin Salih Semiz¹, Halil Ibrahim Ellez¹, Suleyman Ozkan Aksoy³, Isil Basara Akin⁴, Duygu Gurel⁵, Aziz Karaoglu^1
1Department of Medical Oncology, Dokuz Eylül University, Izmir, Türkiye, ²Department of Internal Medicine, Dokuz Eylül University, Izmir, Türkiye, ³Department of General Surgery, Dokuz Eylul University Faculty of Medicine, Izmir, Türkiye, ⁴Department of Radiology, Dokuz Eylul University Faculty of Medicine, Izmir, Türkiye, ⁵Department of Pathology, Dokuz Eylul University Faculty of Medicine, Izmir, Türkiye

Objectives: We aimed to investigate the relationship between mammographic density (MD) category and pathological complete response (pCR) in patients with locally advanced breast cancer receiving neoadjuvant chemotherapy. Methods: The study population consisted of 98 breast cancer patients. At the time of diagnosis, MD was categorised according to BIRADS 5th Edition. pCR was defined as the absence of residual tumour cells in the breast and axilla after completion of neoadjuvant chemotherapy (NACT). Results: Patients with less dense breast density (MD category A+B) were significantly older than patients with more dense breast density (MD category C+D) (p=0.001). When patients were divided according to BIRADS classification (A/B and C/D), there was no statistical difference in performing pCR between patients with high MD and patients with low MD (p=0.684 ;%95 GA 0.67-0.69). Conclusion: In previous studies, conflicting results were obtained in the relationship between MD value and treatment response. In our study, MD was not an independent predictor of response to breast cancer NACT. Keywords: Breast Cancer, density, pathological complete response, mammographic density

---

Cite This Article

Uzun M, Kurtulus E, Caliskan Yildirim E, Unek I, Semiz H, Ellez H, Aksoy S, Basara Akin I, Gurel D, Karaoglu A. Does Mammographic Density Predict Pathological Complete Response in Patients with Locally Advanced Breast Cancer Receiving Neoadjuvant Chemotherapy?. EJMI. 2023; 7(2): 175-180

Corresponding Author: Mehmet Uzun

Full Text PDF PDF Download