The Ratio of Hemoglobin to Red Cell Distribution Width Predicts Pathological Complete Response with Rectal Cancer Treated by Neoadjuvant Chemoradiotherapy
Mehmet Aslan1, Esma Turkmen Bekmaz21Department of Surgical Oncology, University of Health Sciences Derince Training and Research Hospital, Kocaeli, Türkiye, 2Department of Medical Oncology, University of Health Sciences Derince Training and Research Hospital, Kocaeli, Türkiye
Objectives: Concurrent neoadjuvant chemoradiotherapy followed by total mesorectal excision is the standard treatment for locally advanced rectal cancer (LARC). Approximately 20% of patients achieved pathological complete response (pCR) after neoadjuvant treatment. This study aimed to evaluate the relationship between the ratio of hemoglobin to red cell distribution (HRR) width and response to neoadjuvant chemoradiotherapy for rectal cancer. Methods: We retrospectively analyzed patients with locally advanced rectal cancer who underwent neoadjuvant chemoradiotherapy followed by surgery between July 2014 and March 2020. The effects of hematological parameters on the response to neoadjuvant chemoradiotherapy were analyzed. Results: A total of 49 patients were eligible for analysis. Red blood cell distribution width (p=0.04), lower systemic immune-inflammation index (p=0.03), and a higher pre-chemoradiotherapy ratio of hemoglobin to red cell distribution width (p=0.03) were associated with a pathological complete response. The multivariate analysis showed that pretreatment ratio of hemoglobin to red cell distribution width >0.88 significantly predicted a complete pathological response, and it was an independent predictor of complete histological response (p=0.009, OR:8, %95 CI: (1,69–37,6). Conclusion: The ratio of hemoglobin to red cell distribution width can be used to predict complete pathological response in rectal cancer patients receiving neoadjuvant treatment. Keywords: Complete Response, Rectal Cancer, Ratio of Hemoglobin to Red Cell Distribution Width
Cite This Article
Aslan M, Bekmaz E. The Ratio of Hemoglobin to Red Cell Distribution Width Predicts Pathological Complete Response with Rectal Cancer Treated by Neoadjuvant Chemoradiotherapy. EJMI. 2023; 7(3): 283-289
Corresponding Author: Esma Turkmen Bekmaz