Impact of Neutrophil to Lymphocyte Ratio on Pathological Response to Neoadjuvant Chemotherapy in Nonmetastatic Breast Cancer
Ender Dogan1, Ebru Akay2, Saliha Karagoz Eren3, Gamze Turk41Department of Medical Oncology, Kayseri City Training and Research Hospital, Kayseri, Türkiye, 2Department of Pathology, Kayseri City Training and Research Hospital, Kayseri, Türkiye, 3Department of Surgery, Kayseri City Training and Research Hospital, Kayseri, Türkiye, 4Department of Radiology, Kayseri City Training and Research Hospital, Kayseri, Türkiye
Objectives: Recent reports showed an association between tumor progression and systemic inflammatory response. It was suggested that increased neutrophil lymphocyte ratio were associated with reduced pathological complete response rates after neoadjuvant chemotherapy. We aimed to investigate the relationship between pretreatment NLR and pathological response rates in nonmetastatic breast cancer patients who received neoadjuvant chemotherapy. Methods: We retrospectively reviewed 67 patients who were diagnosed with breast cancer and received neoadjuvant chemotherapy at Kayseri City Hospital. NLR was calculated before neoadjuvant chemotherapy and we determined a cut off value. Low and high NLR were compared according to general characteristics. And the factors that predict complete response analysed using logistic regression analysis. Results: There were no statistically significant difference among NLR low and high groups according to general characteristics. Both the univariate and multivariate analyses revealed that histological subtype, grade, hormone receptor status, HER2 status were correlated with complete response. Conclusion: In this study there were no relationship between NLR and pathological complete response rate. As expected we showed that the histological subtype, grade, hormone receptor status, HER2 status were independent markers to predict complete response. Keywords: Breast cancer, neutrophil-lymphocyte ratio, neoadjuvant chemotherapy
Cite This Article
Dogan E, Akay E, Eren S, Turk G. Impact of Neutrophil to Lymphocyte Ratio on Pathological Response to Neoadjuvant Chemotherapy in Nonmetastatic Breast Cancer. EJMI. 2023; 7(4): 482-486
Corresponding Author: Ender Dogan