Objectives: Recent reports showed an association between tumor progression and systemic inflammatory response. It was suggested that increased neutrophil lymphocyte ratio were associated with reduced pathological complete response rates after neoadjuvant chemotherapy. We aimed to investigate the relationship between pretreatment NLR and pathological response rates in nonmetastatic breast cancer patients who received neoadjuvant chemotherapy. Methods: We retrospectively reviewed 67 patients who were diagnosed with breast cancer and received neoadjuvant chemotherapy at Kayseri City Hospital. NLR was calculated before neoadjuvant chemotherapy and we determined a cut off value. Low and high NLR were compared according to general characteristics. And the factors that predict complete response analysed using logistic regression analysis. Results: There were no statistically significant difference among NLR low and high groups according to general characteristics. Both the univariate and multivariate analyses revealed that histological subtype, grade, hormone receptor status, HER2 status were correlated with complete response. Conclusion: In this study there were no relationship between NLR and pathological complete response rate. As expected we showed that the histological subtype, grade, hormone receptor status, HER2 status were independent markers to predict complete response. Keywords: Breast cancer, neutrophil-lymphocyte ratio, neoadjuvant chemotherapy
Corresponding Author: Ender Dogan