Evaluation of Clinicopathological Characteristics and Survival Outcomes of Young Gastric Cancer Patients, Single Center Experience
Rukiye Arikan1, Tugba Akin Telli2, Selver Isik1, Murat Sari1, Osman Kostek1, Ozlem Ercelep1, Ibrahim Vedat Bayoglu11Department of Internal Medicine, Division of Medical Oncology, Marmara University Faculty of Medicine, Istanbul, Türkiye, 2Department of Internal Medicine, Division of Medical Oncology, Memorial Hospital, Istanbul, Türkiye
Objectives: We aimed to evaluate clinicopathological features and survival outcomes of young gastric cancer (YGC) patients. Methods: We retrospectively evaluated data of gastric cancer (GC) patients (? 45 years old) who were followed-up in our center between 2008-2018. Results: We included 130 patients (66 males, 64 females) with a median age of 38 years. Proportion of tumor node metastasis (TNM) stage ? was 50.8%. Seventy-nine patients underwent surgical resection. The most common sites of metastasis were peritoneum, distant lymph node, and liver. The median follow-up period was 19.6 months (range: 1.3 – 181.8 months). During the follow-up period, 26 (40.7%) patients had developed recurrence, and 92 (70.8%) patients had died. DFS rates at 1-, 3-, 5-years were 86%, 68%, 65%, respectively. Median overall survival (OS) was 19.6 months (95% Confidence Interval: 13.9 – 25.4) and OS rates at 1-, 3-, 5- years were 69%, 37%, 33%, respectively, regardless of TNM stage. Conclusion: The study revealed nearly equal sex ratio, high frequency in diffuse type histology, undifferatiated tumor, proximal location, advanced stage and peritoneum metastasis in YGC patients. While DFS was similar, OS was relatively low compared to the literature. Our results emphasize the importance of early diagnosis in YGC patients. Keywords: Gastric cancer, prognosis, young age
Cite This Article
Arikan R, Telli T, Isik S, Sari M, Kostek O, Ercelep O, Bayoglu I. Evaluation of Clinicopathological Characteristics and Survival Outcomes of Young Gastric Cancer Patients, Single Center Experience. EJMI. 2023; 7(3): 296-302
Corresponding Author: Rukiye Arikan