LODDS and Other Prognostic Factors in Medullary Thyroid Cancers, Single Center Experience
Huseyin Gobut1, Cagri Buyukkasap11Department of General Surgery, Gazi University Faculty of Medicine, Ankara, Türkiye
Objectives: This study analyzes patients with medullary thyroid carcinomas (MTC) to determine the factors that affect their survival rates and the value of LODDS values in predicting outcomes, due to the high recurrence and metastasis rates of MTC despite available treatments. Methods: 39 patients who underwent surgical treatment for MTC between January 2012 and June 2022 were evaluated. The effects of clinicopathologic features and LODDS values on survival were evaluated using univariate, multivariate analyses and Kaplan-Meier method. Results: In the study, 51.3% of patients were female, with a mean age of 50.30±15.06 years. Poor prognosis for survival was associated with male gender, tumor size, extrathyroidal extension, presence of metastasis at diagnosis, metastasis during follow-up, advanced stage, lymph node metastasis, and high LODDS value (p=0.031, 0.002, <0.001, 0.045, 0.019, 0.025, 0.025, <0.001, respectively). However, these factors did not significantly affect disease-free survival or overall survival in multivariate analyses. Conclusion: Factors affecting survival in MTC include gender, tumor size, extension, lymph node status, metastasis at diagnosis or follow-up. LODDS values may be a reliable measure to predict survival, but more comprehensive studies are needed to confirm their effect on survival times. Keywords: LODDS, medullary thyroid cancer, prognosis
Cite This Article
Gobut H, Buyukkasap C. LODDS and Other Prognostic Factors in Medullary Thyroid Cancers, Single Center Experience. EJMI. 2023; 7(3): 251-258
Corresponding Author: Cagri Buyukkasap