The Effect of Monocyte Count on Disease-free Survival in Esophageal Cancer Patients
Nurhan Onal Kalkan1, Umut Cakiroglu21Department of Medical Oncology, Batman Training and Research Hospital, Batman, Türkiye, 2Department of Medical Oncology, Yuzuncu Yil University Faculty of Medicine, Van, Türkiye
Objectives: Inflammation plays a pivotal role in cancer development and prognosis. Peripheral blood test is a useful parameter in the evaluation of systemic inflammatory response. The previous studies have shown a relationship between monocyte count and prognosis in some solid tumors. The aim of this study was to evaluate the relationship between the monocyte count assessed at diagnosis and disease-free survival (DFS) on prognosis in patients with esophageal cancer. Methods: The retrospective study included 145 patients with esophageal cancer who presented to Van Training and Research Hospital Medical Oncology outpatient clinic between January 2015 and September 2020. The effect of monocyte count assessed in the blood samples taken at the time of diagnosis before the initiation of the treatment on DFS was investigated. Results: The receiver operating characteristics curve analysis determined a cutoff value of 515/?L for the monocyte count assessed at the time of diagnosis. DFS was 17.3 months (95% CI: 8.4–26.2) in patients with a monocyte count ?515/?L as opposed to 38.5 months (95% CI: 28. 8–48.1) in patients with a monocyte count <515/?L. Moreover, low monocyte count at diagnosis was associated with significantly higher DFS (p<0.001). Conclusion: It is considered that the proportional distribution of cells in peripheral blood count may reflect the severity of inflammation in the tumor microenvironment. Tumor-associated macrophages are a well-known component of the inflammatory infiltrate in the tumor microenvironment, originating from monocytes. Our findings showed that monocyte count is a prognostic factor affecting DFS in patients with esophageal cancer, regardless of histological subtype. Keywords: Disease-free survival, esophageal cancer, monocyte count, tumor associated macrophages
Cite This Article
Onal Kalkan N, Cakiroglu U. The Effect of Monocyte Count on Disease-free Survival in Esophageal Cancer Patients. EJMI. 2023; 7(3): 203-208
Corresponding Author: Nurhan Onal Kalkan