Prognostic Significance of Combined Inflammatory Index (CII) in Nodular Lymphocyte Predominant Hodgkin Lymphoma
Semra Paydas1, Merih Kizil Cakar2, Ibrahim Barista3, Gulsah Seydaoglu1, Metin Pehlivan4, Mutlu Dogan5, Fevzi Altuntas21Department of Medical Oncology, Çukurova University Faculty of Medicine, Adana, Türkiye, 2Department of Hematology, University of Health Sciences, Ankara Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Türkiye, 3Department of Medical Oncology, Hacettepe University Faculty of Medicine, Ankara, Türkiye, 4Department of Medical Oncology, İstanbul University Faculty of Medicine, Istanbul, Türkiye, 5Department of Medical Oncology, University of Health Sciences, Ankara Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Türkiye
Objectives: Inflammatory indexes are shown to have clinical significance in cancer. We aimed to determine the prognostic significance of a novel scale index as combined inflammatory index (CII) including leukocyte/lymphocyte ratio(LLR) & prognostic nutritional index(PNI) in nodular lymphocyte predominant Hodgkin Lymphoma(NLPHL) comparing them with well-known prognostic factors. Methods: 101 patients were evaluated retrospectively. Cut-offs were 3.9 for LLR and 53.5 for PNI by ROC analyses. A novel scale-index (‘combined inflammatory index-CII’) was obtained by the combination of LLR and PNI. Results: There was a moderate negative correlation between PNI and LLR (r=-0,66). In univariate analyses, advanced stage, bone marrow infiltration(BMI), B symptoms, lymphocytopenia, hypoalbuminemia, higher LLR(?3.9) and lower PNI(?53.5) were found to be significant prognostic factors. In multivariate analyses, LLR, PNI and CII were found to be independent significant risk factors for PFS while the models were standardized by age, stage, anemia, hypoalbuminemia, B symptoms & bulky disease. Conclusion: Prognostic score examining LLR and PNI besides other clinical parameters showed that patients in high risk group (higher LLR and lower PNI) had shortest PFS. In conclusion, a scoring system combining LLR and PNI is a novel scoring system in NLPHL.Combined inflammatory index-CII can be used as a prognostic factor in NLPHL. Keywords: Combined inflammatory index, CII, LLR, nodular lymphocyte predominant hodgkin lymphoma, PNI
Cite This Article
Paydas S, Kizil Cakar M, Barista I, Seydaoglu G, Pehlivan M, Dogan M, Altuntas F. Prognostic Significance of Combined Inflammatory Index (CII) in Nodular Lymphocyte Predominant Hodgkin Lymphoma. EJMI. 2023; 7(3): 235-245
Corresponding Author: Mutlu Dogan