Does Hypoxia Inducible Factor 1? Levels Contribute to the Diagnosis and Follow Up of Carbon Monoxide Poisoning?
Hakan Hakkoymaz1, Muhammed Semih Gedik1, Selcuk Nazik2, Muhammed Seyithanoglu31Department of Emergency Medicine, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Türkiye, 2Department of Infectious Diseases and Clinical Microbiology Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Türkiye, 3Department of Medical Biochemistry, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Türkiye
Objectives: This study aimed to evaluate the levels of HIF-1? (Hypoxia-Induced Factor) in acute Carbonmonoxide poisoning (COP) at admission and after the treatment. Methods: The study was conducted prospectively and cross-sectionally in the adult Emergency Department of our hospitalbetween 01.01.2018 and 30.06.2018. Results: This study included 42 patients admitted to the emergency department with suspected COP. When the cases were grouped according to carboxyhemoglobin (COHb) level, the levels of 38.1% (n=16) and 61.5% (n=26) of the patients were found to be moderate and severe, respectively. There were no mild cases among our cases. After the treatment, HIF-1?, COHb, mean platelet volume (MPV), lymphocyte, lactate, pH and base deficit values were statistically significantly lower than the pre-treatment values(p value<0.0001, <0.0001, <0.0001, 0.039, <0.0001, 0.032, 0.01, respectively). A positive correlation was found between COHb level and white blood cell (WBC), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), pH, HIF-1? and lactate levels. There was a statistical significance only at pH value (p=0.001, r=0.474). Conclusion: HIF-1? increases significantly in parallel withCarbonmonoxide(CO) exposure and these high levels are positively correlated with COHb concentrations. Based on this data, COHb concentrations are still the best biomarkers in the diagnosis and follow-up of COP. Keywords: Carbonmonoxide poisoning, HIF-1?, COHb, Emergency department, Toxicology
Cite This Article
Hakkoymaz H, Gedik M, Nazik S, Seyithanoglu M. Does Hypoxia Inducible Factor 1? Levels Contribute to the Diagnosis and Follow Up of Carbon Monoxide Poisoning?. EJMI. 2023; 7(4): 394-400
Corresponding Author: Muhammed Semih Gedik