The Examination of Galectin-3 Levels in Children with Attention Deficit and Hyperactivity Disorder
Abdulbaki Artik1, Orhan Kocaman1, Halil Kara21Department of Child and Adolescent Mental Health, Gulhane Training and Research Hospital, Ankara, Türkiye Department of Child and Adolescent Mental Health, Gulhane Training and Research Hospital, Ankara, Türkiye, 2Department of Child and Adolescent Mental Health, Gulhane Training and Research Hospital, Ankara, Türkiye
bjectives: The etiopathogenesis of ADHD involves genetic, environmental, psychological, and brain structural variables. Inflammation is one ADHD etiology study field. Galectin-3 may enhance inflammation by inhibiting the antiinflammatory cytokine interleukin-10 (IL-10). This study examined the link between blood galectin-3 concentrations and ADHD severity and levels in children with ADHD. Methods: The clinic treated 34 first-time ADHD patients aged 5.2-14.1. Non-psychotropic first-time diagnoses were chosen. Patients were compared to 21 age- and gender-matched healthy controls. After a paediatrician exam, a psychiatrist screens healthy controls for mental illness using the Schedule for Mood Disorders and Schizophrenia in SchoolAge Children, Now and Lifetime Version-DSM-5 (K-SADS-PL-DSM-5). Conners' Parent Rating Scale (CPRS) and Conners' Teacher Rating Scale( CTRS) were used for diagnosis by a child and adolescent psychiatrist. Results: Mean serum galectin-3 levels were compared between ADHD group and control groups. Serum galectin-3 level was 428.6 (SD±194.4) in the ADHD group and 183.7 ng/ml (SD±49.6) in the control group. ADHD group is found to have statistically significantly higher galectin-3 concentrations when compared to the control group (z=-5.15, p<.001). Conclusion: In our study, it was found that serum galectin-3 levels were higher in children with ADHD and there was a significant correlation between ADHD severity and serum galectin-3 levels. Based on these findings, it is thought that galectin-3 may be associated with the etiopathogenesis of ADHD. Keywords: ADHD, Galectin-3 Levels, Inflammation
Cite This Article
Artik A, Kocaman O, Kara H. The Examination of Galectin-3 Levels in Children with Attention Deficit and Hyperactivity Disorder. EJMI. 2023; 7(4): 414-418
Corresponding Author: Abdulbaki Artik