EJMI. 2022; 6(4): 443-449 | DOI: 10.14744/ejmi.2022.98161

Impact of Prognostic Nutritional Index on Long-Term Outcomes in Patients with Gastric Cancer: Izmir Oncology Group (IZOG) Study

Yasar Yildiz¹, Burcin Dalkilinc¹, Adem Sengul², Ozlem Ozdemir¹, Ahmet Alacacioglu¹, Utku Oflazoglu¹, Seray Saray¹, Mehmet Eren Kalender¹, Umut Varol¹, Tarik Salman¹, Betul Bolat Kucukzeybek¹, Zeynep Guc¹, Sinan Unal¹, Yuksel Kucukzeybek^3
1Department of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Türkiye, ²Department of Radiation Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Türkiye, ³Department of Pathology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Türkiye

Objectives: We aimed to investigate the effect of the Prognostic Nutritional Index (PNI) and other well?known prognostic factors in gastric cancer (GC) patients based on pathological parameters and to analyze its predictive value for gastric cancer survival. Methods: The PNI was calculated by using serum albumin and total lymphocyte count on the time diagnosis. Associations between PNI and clinical, demografic and histopathological parameters were analyzed. Results: Data of 364 patients with GC were evaluated retrospectively. The median OS was 27 months (95%CI, 20.3 to 33.6)) in the high prognostic nutrition index and 14 months (95%CI, 11.5 to 16.4) in the low prognostic nutrition index (p<0.0001). In the multivariate Cox regression model, prognostic nutrition index (B=0.410, 95% CI=1.023 to 2.221 p=0.038), lymphovascular invasion (B=.907, 95% CI=1.398 to 4.390 p=0.002), stage (B=0.842 95% CI=1.349 to 3.992 p=0.002) and lymph node metastasis (B=-.896, 95% CI=1.199 to 4.908 p=0.014) were statistically significant predictors for OS. Conclusion: The PNI, a simple, well-validated, and cost-effective biomarker is an independent prognostic factor for OS in patients with GC. Our results can emphasize prognostic benefit from careful nutritional support during diagnosis and treatment for patients with poor nutritional parameters. Keywords: Prognostic nutrition index, gastric cancer, survival

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Cite This Article

Yildiz Y, Dalkilinc B, Sengul A, Ozdemir O, Alacacioglu A, Oflazoglu U, Saray S, Kalender M, Varol U, Salman T, Kucukzeybek B, Guc Z, Unal S, Kucukzeybek Y. Impact of Prognostic Nutritional Index on Long-Term Outcomes in Patients with Gastric Cancer: Izmir Oncology Group (IZOG) Study. EJMI. 2022; 6(4): 443-449

Corresponding Author: Yasar Yildiz

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