Importance of Prognostic Nutritional Index in Patients with Metastatic Breast Cancer Treated with Trastuzumab Emtansine
Tolga Koseci1, Gulcan Bulut2, Serdar Ata3, Ertugrul Bayram4, Timucin Cil3, Kadir Esen51Department of Medical Oncology, Cukurova University, Adana, Türkiye, 2Department of Medical Oncology, Medicana International İzmir Hospital, İzmir, Türkiye, 3Department of Medical Oncology, University of Health Science, Adana City Teaching and Research Hospital, Adana, Türkiye, 4Department of Oncology, Cukurova University, Adana, Türkiye, 5Department of Oncology, Mersin University, Mersin University Hospital, Mersin, Türkiye
Objectives: Trastuzumab emtansine(T-DM1) is more effective in some patients. However, predictive factors are not clear for T-DM1 efficacy. We attempt to explore prognostic importance of albumin to alkaline phosphotase ratio (AAPR) and prognostic nutritional index (PNI) importance in patients who used T-DM1. Methods: The present retrospective study included the sixty-one human epidermal growh factor-2 (HER-2) positive metastatic breast cancer patients who used T-DM1. The median values were used to analyze AAPR and PNI threshold. PNI and AAPR were measured at baseline and after one cycle. Survival analysis was performed by using Kaplan-Meier method and compared with log rank test. Univariate and multivariate analysis were performed to determine independent prognostic predictor of progression-free survival (PFS) and overall survival (OS). Results: The optimal cutoff value for AAPR and PNI were 0.41 and 45.0, respectively. OS and PFS were obviously inferior in patients with AAPR<0.41 compared to patients with AAPR?0.41 according to Kaplan-Meier curve (OS: p=0.028, PFS: p=0.047). Patients with PNI <45 prominently demonstrated poor OS and PFS than those with PNI?45 according to Kaplan-Meier curve (OS: p=0.033, PFS: p=0.071). Conclusion: Pretreatment PNI is reliable prognostic indicators in patients with mBC treated by T-DM1. Keywords: Albumin to alkaline phosphotase ratio, overall survival, prognostic nutritional index, trastuzumab emtansine
Cite This Article
Koseci T, Bulut G, Ata S, Bayram E, Cil T, Esen K. Importance of Prognostic Nutritional Index in Patients with Metastatic Breast Cancer Treated with Trastuzumab Emtansine. EJMI. 2022; 6(4): 484-490
Corresponding Author: Tolga Koseci