E-ISSN 2602-3164
EJMI. 2022; 6(2): 190-197 | DOI: 10.14744/ejmi.2022.80484

Could ARNI have an Effect on LV Fibrosis and Inflammatory Parameters in an Experimental Autoimmune Myocarditis Model?

Ali Duygu1, Emine Gazi2, Bulent Deveci3, Mehmet Arslan4, Rahime Ozlem Oztopuz5, Yasemin Adali6
1Department of Cardiology, Bursa Yenişehir State Hospital, Bursa, Turkey, 2Department of Cardiology, Canakkale Onsekiz Mart University, Canakkale, Turkey Turkey, 3Department of Cardiology, Ministry of Health Ankara City Hospital, Ankara, Turkey Turkey, 4Department of Cardiology, Canakkale Mehmet Akif Ersoy State Hospital, Turkey Çanakkale, Turkey, 5Department of Biophysics, Canakkale Onsekiz Mart University, Canakkale, Turkey Turkey, 6Department of Pathology, İzmir University of Economics, İzmir, Turkey

Objectives: The aim of this study is to investigate the efficacy of sacubitril-valsartan treatment in the early period of Experimental Autoimmune Myocarditis (EAM) model, under the perspective of fibrosis and inflammatory cytokines. Methods: The study was performed using 18 rats in three groups of EAM, Treatment, and control. EAM was induced by footpad injections of porcine cardiac myosin and Complete Freund’s Adjuvant (CFA). The EAM group was not given medical care. 20 mg/kg sacubitril-valsartan was given to Treatment group twice a day beginning from the 21st day to the 42nd day. Histopathological, biochemical and RT-PCR analyses were performed on the heart tissues taken after the 42nd day of sacrificing. Results: Significant congestion and fibrosis were observed in the EAM and Treatment groups. There was 50% less severe fibrosis,which is 3rd degree, in the Treatment group compared to EAM. Severe congestion rate was lower in the treatment group compared to EAM; with the percentage of 16,6% to 50%. Conclusion: In view of findings, the treatment of ARNI in acute autoimmune myocarditis may be promising on cardiac risk markers (cytokine, BNP values) and fibrosis parameters. Studies to be conducted in high-numbered groups will reveal more statistical significance. Keywords: Sacubitril/Valsartan, experimental myocarditis, heart failure, fibrosis, Wistar rat


Cite This Article

Duygu A, Gazi E, Deveci B, Arslan M, Oztopuz R, Adali Y. Could ARNI have an Effect on LV Fibrosis and Inflammatory Parameters in an Experimental Autoimmune Myocarditis Model?. EJMI. 2022; 6(2): 190-197

Corresponding Author: Ali Duygu

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