Objectives: The aim of this study was to evaluate the possibility of malignancy among thyroid nodules by different age and gender. Methods: We retrospectively evaluated the biopsy results of 609 consecutive patients who underwent thyroid fine needle aspiration biopsy (FNAB) between 2010 and 2019 according to the Bethesda classification system and tried to determine the possible effect of patient age and gender on thyroid nodule malignancy by FNAB. Results: The mean age of the whole group was 50.4±13.4 (13-96) years. This study included a total of 609 patients of whom 481 (79%) were women and 128 (21%) were men. The pathology results of the nodules were mostly benign (78.3%) followed by AUS at a rate of 9.5%. There was an inverse relationship between age and malignancy. As in younger ages, malignancy rate increased significantly (p<0.01). The risk of malignancy decreased with increasing age in both male and female trend with age showin a statistically significant difference in female (p=0.002), but not in male (p=0.064). Conclusion: In the case of a thyroid nodule at any age patients should be informed there may be a risk for thyroid cancer requiring continued monitoring. Keywords: Age, gender, thyroid cancer
Corresponding Author: Serkan Celik