E-ISSN 2602-3164
EJMI. 2022; 6(3): 352-358 | DOI: 10.14744/ejmi.2022.38653

A Laboratory Prognostic Index Model for Predicting Survival in Patients with Malignant Pleural Mesothelioma

Tugba Basoglu1, Nazim Can Demircan1, Tugce Kubra Gunes1, Mehmet Umut Capar1, Merve Cinar1, Rukiye Arikan1, Tugba Akin Telli1, Ozlem Ercelep1, Faysal Dane1, Perran Fulden Yumuk1
1Department of Medical Oncology, Faculty of Medicine, Marmara University, Istanbul, Turkey

Objectives: The prognostic significance of a Laboratory Prognostic Index (LPI) was demonstrated recently in non-small cell lung cancer (NSCLC). We investigated the predictive effect of LPI in patients with malignant pleural mesothelioma (MPM). Methods: We retrospectively reviewed 68 patients with MPM in a single institution. LPI score was consist of serum levels of white blood cells (WBC?10000/mm3 ), lactate dehydrogenase (LDH?248 U/L), albumin (?3.5 g/dL), calcium (Ca?10.5 mg/dL), and alkaline phosphatase (ALP?120 U/L). Patients were classified into 3 LPI groups as follows: LPI0:normal; LPI1:with one abnormal laboratory finding; and LPI2:with at least 2 abnormal laboratory findings. Results: The study included 53 patients with MPM. Median follow-up period was 11.4 (1-103) months. Median OS of all patients was 21.6 months (95% CI; 15.9–27.4). When patients were classified by LPI; median OS was 36.5 months (95%CI, 13.6-59.3) in patients with LPI0, 23.7 month s(95%CI, 19.8-27.6) with LPI1 and 11.5 months (95%CI, 5.5-17.6) with LPI2 (p=0.001). According to multivariate analysis higher LPI score at the time of diagnosis were independent poor prognostic variables for OS (p<0.05). Conclusion: In this study, LPI was found to be a significant prognostic factor for OS in patients with MPM. LPI can be used as a non-invasive, easily applicable, practical prognostic factor in mesothelioma patients. We believe that this prognostic score meets the of unmet need on this subject in the literature. Keywords: Laboratory Prognostic Index(LPI), malignant, mesothelioma, survival analysis.

Cite This Article

Basoglu T, Demircan N, Gunes T, Capar M, Cinar M, Arikan R, Telli T, Ercelep O, Dane F, Yumuk P. A Laboratory Prognostic Index Model for Predicting Survival in Patients with Malignant Pleural Mesothelioma. EJMI. 2022; 6(3): 352-358

Corresponding Author: Tugba Basoglu

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