Association Between Dosimetric and Toxicity Findings Using Hypo-Fractionated Whole Breast Radiotherapy: A Long-Term Experience
Ayfer Ay Eren1, Evren Goksel2, Cenk Umay3, Mehmet Fuat Eren4, Nuran Bese51Department of Radiation Oncology, Kartal Dr. Lutfi Kırdar City Hospital, İstanbul, Türkiye, 2Department of Radiation Oncology, Acıbadem University, İstanbul, Türkiye, 3Department of Radiation Oncology, Dokuz Eylül University Medical Faculty, İzmir, Türkiye, 4Department of Radiation Oncology, İstanbul Marmara University Pendik Training and Research Hospital, İstanbul, Türkiye, 5Department of Radiation Oncology, Acıbadem University, Maslak, İstanbul, Türkiye
Objectives: This study aimed to assess the toxicity and cosmetic outcomes in breast cancer patients treated with hypofractionated radiotherapy (HFRT) and identify the risk factors for toxicity. Methods: 56 women with early-stage breast cancer were enrolled in this study. We evaluated physician-rated acute and late RTOG toxicity criteria and cosmetic outcomes during and after RT. Results: The median age was 64. The median follow-up was 90 months. By the end of RT, 29 of 56 (52 %) patients had no acute toxicity according to the RTOG criteria, while 27 (48%) developed grade 1 and grade 2 acute skin toxicity. Twelve patients developed grade 1 edema and skin hyperemia six months after radiotherapy. In contrast, no worse late skin toxicity was observed in 1 year and five-year follow-ups. Multivariate analyses showed that skin toxicity correlated with surgery type (p=0.043), axillary dissection (p=0.032), and supraclavicular radiotherapy (p=0.043). Conclusion: These results verified the viability and safety of HFRT in patients with early breast cancer. Surgery type, axillary surgery type, and supraclavicular radiotherapy were significant adverse prognostic factors for late toxicity. Longterm follow-up is required to confirm this finding. Keywords: Acut toxicity, hypo-fractionated whole breast radiotherapy, late toxicity
Cite This Article
Ay Eren A, Goksel E, Umay C, Eren M, Bese N. Association Between Dosimetric and Toxicity Findings Using Hypo-Fractionated Whole Breast Radiotherapy: A Long-Term Experience. EJMI. 2023; 7(1): 16-22
Corresponding Author: Ayfer Ay Eren