Imaging Features and Histopathological Analysis in Patients with Subcentimeter Breast Cancer Detected by Ultrasonography
Nurdan Fidan1, Cuneyt Yucesoy2, Zeynep Banu Aydın1, Unsal Han3, Betul Bozkurt41Department of Radiology, Faculty of Medicine, Hitit University,Corum, Turkey., 2Department of Radiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey., 3Department of Pathology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey., 4Department of Surgery, Faculty of Medicine, Hitit University,Corum, Turkey.
Objectives: We aimed to present preoperative ultrasonographic features, distribution of histopathological diagnosis and molecular subtypes of malignant tumors, and to compare sonographic and pathological tumor dimensions in patients with subcentimeter breast lesions. Methods: Eighty six women with newly diagnosed breast cancer were included in the study who underwent preoperative biopsy and surgical resection between 2015 and 2020. Sonographically tumor margins were grouped as circumscribed, microlobulated, irregular-indistinct, angular and spiculated. By taking 25% of the pathological tumor size and value of ± 5 mm as cut-off, the presence of sonopathological concordance was evaluated. Results: The median tumor sizes were 10 mm (4-10 mm) sonographically and 11 mm (2-45 mm) histopathologically. The spiculated and irregular-indistinct margins were the most frequent sonog-raphic features (35% and 35%). Value of ±5 mm and 25% of the pathological tumor size acording to cut-off, the sonopathological concordance rates were calculated as 74% and 55%, the underestimation rates were 20% and 35%, the overestimation rates were 6% and 10%, respectively. Conclusion: In our study, the most common sonographic features was spiculated and irregular-indistinct margins. We found sonopathological concordance rates similar to current literature. Especially in patients with DCIS, invasive lobular carcinoma, and HER2 enriched subtype, sonopathological discordance should be considered when planning the optimal treatment. Keywords: Breast cancer, concordance, ultrasonography, tumor size, subcentimeter
Cite This Article
Fidan N, Yucesoy C, Aydın Z, Han U, Bozkurt B. Imaging Features and Histopathological Analysis in Patients with Subcentimeter Breast Cancer Detected by Ultrasonography. EJMI. 2022; 6(3): 304-311
Corresponding Author: Nurdan Fidan