Predictive Importance of Vitamin D on Response to Neoadjuvant Chemotherapy in Turkish Patients with Locally Advanced Hormone Receptor Positive Breast Cancer
Muhammed Mustafa Atci1, Ruhper Cekin11Department of Medical Oncology, University of Health Sciences, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey
Objectives: To investigate the relationship between the level of vitamin D with pathological response rates to neoadjuvant chemotherapy in breast cancer patients. Methods: The pathological responses of patients treated with neoadjuvant chemotherapy for locally advanced breast cancer regarding Miller-Payne grading system were noted as ?90% and >90% response. Vitamin D deficiency was defined as <20 ng/mL. Results: Eighty-nine patients with a mean age of 49.7±12.1 years old were included. Forty-two (47.2%) patients were postmenopausal. Vitamin D deficiency was present in 38 (42.7%) patients. Forty-eight (53.9%) and 41 (46.1%) patients had a pathological response rate of ?90 and >90 to neoadjuvant chemotherapy, respectively. In univariate analysis, tumor size, menopause status, and histologic grade were found to be statistically significant for pathological response. In multivariate analysis, progesteron receptor positivity, premenopause, and higher tumor diameter were associated with decreasing pathologic response. The level of vitamin D was not statistically significant on pathological response to neoadjuvant chemotherapy. Conclusion: The level of vitamin D level was not associated with pathologic response rates to neoadjuvant chemotherapy in Turkish population. This may be explained with vitamin D receptor polymorphism in different ethnicities which should be evaluated in future studies in terms of pathologic response to neoadjuvant chemotherapy. Keywords: Breast cancer, neoadjuvant chemotherapy, pathologic response, vitamin D
Cite This Article
Atci M, Cekin R. Predictive Importance of Vitamin D on Response to Neoadjuvant Chemotherapy in Turkish Patients with Locally Advanced Hormone Receptor Positive Breast Cancer. EJMI. 2021; 5(3): 388-393
Corresponding Author: Muhammed Mustafa Atci