E-ISSN 2602-3164
EJMI. 2021; 5(4): 435-440 | DOI: 10.14744/ejmi.2021.89773

Systemic Immune-Inflammation Index is a Novel Marker to Predict Contrast-Induced Acute Kidney Injury

Murat Gucun1, Okan Akyuz1, Emrah Bayram2, Ender Ozgun Cakmak2
1Department of Nephrology, Health Sciences University, Kartal Kosuyolu Heart and Research Hospital, Istanbul, Turkey, 2Department of Cardiology, Health Sciences University, Kartal Kosuyolu Heart and Research Hospital, Istanbul, Turkey

Objectives: Systemic immune-inflammation index (SII) is a novel marker based on blood peripheral platelet, neutrophil, and lymphocyte counts. We aimed to evaluate the worth of a SII in predicting contrast-induced nephropathy. Methods: A total number of 190 consecutive patients who underwent emergency percutaneous coronary intervention were included in the study. Patients were divided into two groups, according to contrast-induced acute kidney injury (CI-AKI) development. Patients with an increase in serum creatinine of ? 0.5 mg/dL or a 25% increase from baseline assessed 48-72 hours after angiography without an alternative explanation were considered CI-AKI. SII is calculated with a formula of total platelet count x total neutrophil count / total lymphocyte count. Results: Two groups were assigned according to CI-AKI development. CI-AKI (+) group included 33 patients, and CIAKI (-) group included 157 patients. CI-AKI developed patients with higher serum creatinine levels, NLR (NeutrophilLymphocyte Ratio), and SII levels. Whereas, in the non-CI-AKI group, e-GFR, serum albumin levels, and ejection fraction were higher. Multivariable logistic regression analysis revealed that higher SII (p=0.001, [OR]=1.002[1001-1004]) were independent risk factors for CI-AKI. Conclusion: The current study demonstrated that SII, a novel marker based on blood peripheral cell counts, is a promising prognostic factor for predicting CI-AKI. Keywords: Systemic immune-inflammation index, contrast-induced acute kidney injury, coronary artery disease


Cite This Article

Gucun M, Akyuz O, Bayram E, Ozgun Cakmak E. Systemic Immune-Inflammation Index is a Novel Marker to Predict Contrast-Induced Acute Kidney Injury. EJMI. 2021; 5(4): 435-440

Corresponding Author: Murat Gucun

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