Prognostic Role of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Patients with HER-2 Positive Brain Metastatic Breast Cancer
Ibrahim Karadag1, Serdar Karakaya1, Ozturk Ates1, Omur Berna Cakmak Oksuzoglu11Department of Medical Oncology, Oncology Training and Research Hospital, Ankara, Turkey
Objectives: Studies have been performed on the parameters that could predict the overall survival (OS) in patients with HER-2 positive breast cancer and have a potential prognostic significance in patients with a high risk of developing brain metastasis. This study was designed to assess the prognostic effect of blood inflammation-based markers, which were previously investigated in various cancers, on OS in brain metastatic HER-2 positive breast cancer. Methods: 105 patients aged over 18 years with positive HER-2 status and brain metastases and no secondary malignancies were included in the study. Inflammation parameters at the time of brain metastasis development and before steroid initiation were taken into consideration. Results: Median OS of the population was determined to be 48 months (40.7-55.30, CI 95%). The median OS after brain metastasis (BM) was 14 months (11.76-16.23, CI 95%) in the whole group, following the development of brain metastasis. A significant negative correlation was found between neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) and OS after BM (r=-0.413 p<0.001 for NLR, r=-0.243 p=0.014 for PLR). It was determined that OS after BM had a negative correlation with neutrophil level and positive correlation with lymphocyte level (r=-0.249 p=0.011 for neutrophils, r=0.268 p=0.006 for lymphocytes). Conclusion: In HER-2 positive brain metastatic breast cancer, increased NLR and PLR levels show a negative prognostic effect on OS after BM, whereas increased lymphocyte count shows a positive prognostic effect. Keywords: Brain Metastasis, Her-2 positive Breast Cancer, NLR, PLR
Cite This Article
Karadag I, Karakaya S, Ates O, Cakmak Oksuzoglu O. Prognostic Role of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Patients with HER-2 Positive Brain Metastatic Breast Cancer. EJMI. 2021; 5(3): 394-397
Corresponding Author: Ibrahim Karadag