Bone Metastases on 18F-FDG PET/CT Imaging in Patients with Colorectal Cancer. Does Bone Scintigraphy Still Have a Role?
Sevda Saglampinar Karyagar1, Savas Karyagar1, Seray Saracoglu1, Binnur Donmez Yilmaz21Department of Nuclear Medicine, University of Health Sciences, Prof. Dr. Cemil Tascioglu City Hospital Faculty of Medicine, Istanbul, Turkey, 2Department of Radiation Oncology, University of Health Sciences, Prof. Dr. Cemil Tascioglu City Hospital Faculty of Medicine, Istanbul, Turkey
bjectives: To analyze the rates, patterns, and features of bone metastases(BM) detected using 18F-FDG PET/CT in patients with colorectal cancer(CRC) and compare them with bone scans (BS) in terms of BM detection. Methods: A total of 920 patients with CRC who underwent 18F-FDG PET/CT scans during the period from Jan 2016 to May 2019 were retrospectively reviewed. Among these, imaging results were compared for 29 patients who underwent BS within 1 month of 18F-FDG PET/CT. Results: In 38(4.1%) patients, 211 BM were detected on 18F-FDG PET/CT imaging. Of 211 BM detected by PET/CT, 42 were osteolytic, 30 were osteoblastic, 55 were mixed, and 84 were CT-negative. Mean SUVmax values of osteoblastic, CT-negative, osteolytic, and mixed lesions were 6.05±2.80, 5.42±2.56, 11.62±6.34 and 8.74±4.48, respectively. A total of 126 BM were detected in 16 of 29 patients who underwent both BS and PET/CT imaging. In patient-based evaluation, the sensitivity, specificity and accuracy of PET/CT and BS were 100%,76.92%,89.66% and 93.75%,46.15%,72.41% and in lesion-based evaluation these values were 99.21%,72.73%,97.08% and 52.38%,0%,48.18%, respectively. Conclusion: 18F-FDG PET/CT is a valuable imaging method for detecting BM in colorectal cancer patients, especially since it can truly detect CT-negative or isolated BM. BS is not required for patients who have undergone PET/CT imaging. Keywords: Bone metastases, bone scan, colorectal cancer, 18F-FDG PET/CT
Cite This Article
Karyagar S, Karyagar S, Saracoglu S, Yilmaz B. Bone Metastases on 18F-FDG PET/CT Imaging in Patients with Colorectal Cancer. Does Bone Scintigraphy Still Have a Role?. EJMI. 2021; 5(2): 218-224
Corresponding Author: Seray Saracoglu