Clinicopathologic and Radiologic Characteristics of Pleomorphic Lobular Breast Cancer
Rukiye Arikan1, Tugba Akin Telli1, Ozkan Alan1, Nazim Can Demircan1, Tugba Basoglu1, Ozlem Ercelep1, Handan Kaya2, Onur Bugdayci3, Umit Ugurlu4, Zerrin Ozgen5, Faysal Dane1, Perran Fulden Yumuk11Department of Internal Medicine, Division of Medical Oncology, Marmara University Faculty of Medicine, Istanbul, Turkey, 2Department of Pathology, Marmara University Faculty of Medicine, Istanbul, Turkey, 3Department of Radiology, Marmara University Faculty of Medicine, Istanbul, Turkey, 4Department of Surgery, Marmara University Faculty of Medicine, Istanbul, Turkey, 5Department of Radiation Oncology, Marmara University Faculty of Medicine, Istanbul, Turkey
Objectives: The objective of the study was to evaluate clinicopathologic and radiologic features of patients with pleomorphic lobular breast cancer (pleomorphic lobular carcinoma [PLC]). Methods: We retrospectively evaluated the clinicopathologic and radiologic features of 25 PLC patients treated in our division from 2012 to 2018. Results: Median age was 50 (range, 42–55) and 48% were postmenopausal. The presence of spiculated mass was 92%. Median tumor size was 21.9 mm (SD±12.7 mm) and axillary lymph node positivity was 44%. Frequency of microcalcification was 12% and frequency of occult breast cancer was 8%. About 72% of patients had Stage 2 or 3 disease. De novo metastatic disease was 8% and another 8% developed metastasis during follow-up. ER, PR, and Her2/neu were positive in 76%, 44%, and 8%, respectively, and 16% of patients were triple negative. All tumors were Grade III. Median Ki-67 was 22% (range 3–90%). Frequency of lymphovascular invasion was 52%. Patients were followed median of 34.5 months (95% CI, 22.2–46.8), since during this period, two patients recurred and five died, median disease-free survival and overall survival could not be reached. Conclusion: Our data suggest that patients with PLC present with poor prognostic features such as large tumor size, axillary lymph node positivity, and high lymphovascular invasion and tumor grade and Ki-67. Keywords: Breast cancer, pleomorphic lobular carcinoma
Cite This Article
Arikan R, Telli T, Alan O, Demircan N, Basoglu T, Ercelep O, Kaya H, Bugdayci O, Ugurlu U, Ozgen Z, Dane F, Yumuk P. Clinicopathologic and Radiologic Characteristics of Pleomorphic Lobular Breast Cancer. EJMI. 2021; 5(1): 148-152
Corresponding Author: Rukiye Arikan