Evaluation of Castration-Resistant Elderly Patients
Serkan Yildirim1, Atike Pinar Erdogan2, Ahmet Ozveren3, Ferhat Ekinci2, Gulcan Bulut41Department of Medical Oncology, Bitlis Tatvan Public Hospital, Bitlis, Turkey, 2Department of Medical Oncology, Celal Bayar University Faculty of Medicine, Manisa, Turkey, 3Department of Medical Oncology, İzmir Kent Hospital, Izmir, Turkey, 4Department of Medical Oncology, Hatay Defne Hospital, Hatay, Turkey
Objectives: In the present time suggesting an extended human lifespan and expectancy, elderly patients receive a significant portion of daily healthcare practice whereas they have not been sufficiently addressed in the extensive and comprehensive clinical studies. We have desgined our study to evaluate the treatment options in this metastatic castration-resistant prostate cancer patients older than 70 years. Methods: Our study is retrospective. The data of the patients from 5 centers of Turkey were obtained. The patients aged 70 years and over were assigned to a group (geriatric group) while the rest of the patients were evaluated in another group (normal group). The primary endpoint of the study was determined as overall survival time. Results: Totally 113 patients were included in our study. The geriatric and normal groups included 58 and 55 patients, respectively. Overall survival as the primary endpoint of our study demonstrated no statistically significant difference between survival of the patients aged over 70 years and other patients (geriatric group versus normal group, respectively 18.86 versus 23.93 months, respectively, p=0,542). Progresion-free survival as the secondary endpoint; no statistically significant difference was detected between two groups (geriatric group vs normal group, median 7.83 vs 8.5 months, respectively, p=0.73). Conclusion: It was detected that the age variable has a negative impact on overall survival of prostate cancer cases. The overall survival was found numerically shorter in the patients aged 70 years and over set as age limit, however, this difference was not found statistically significant. Keywords: Castration resistant, gleason score, geriatric, prostate cancer
Cite This Article
Yildirim S, Erdogan A, Ozveren A, Ekinci F, Bulut G. Evaluation of Castration-Resistant Elderly Patients. EJMI. 2021; 5(2): 251-255
Corresponding Author: Serkan Yildirim