Genetic Abnormalities Detected in Non-Hodgkin Lymphoma
Tuba Bulduk1, Eren Gunduz2, Beyhan Durak Aras3, Busra Emir4, Serap Isiksoy51Department of Hematology, Gulhane Training and Research Hospital, Istanbul, Turkey, 2Department of Hematology, Eskisehir Osmangazi University, Faculty of Medicine, Eskisehir, Turkey, 3Department of Genetics, Eskisehir Osmangazi University, Faculty of Medicine, Eskisehir, Turkey, 4Department of Biostatistics, Eskisehir Osmangazi University, Faculty of Medicine, Eskisehir, Turkey, 5Department of Pathology, Eskisehir Osmangazi University, Faculty of Medicine, Eskisehir, Turkey
Objectives: To investigate the association between clinical features and fluorescence in situ hybridization (FISH) results of patients with non -Hodgkin lymphoma (NHL). The advances in molecular biology, cytogenetics and immunology facilitated the understanding of the pathogenesis of lymphoma. Although there are some basic prognostic indicators, the prognostic importance of genetic factors is gradually increasing. Methods: Fifty six patients who underwent genetic analysis before therapy, were evaluated retrospectively. Deparaffinized lymph node sections were used. Patients were divided into two groups according to the presence of genetic disorder. The groups were compared in terms of clinical features, laboratory parameters and survival. Results: Genetic abnormality was present in 33 of 56 patients. The most common genetic abnormality was MYC/IGH2 rearrangement. There was no difference between the survival of the groups. There was a positive correlation between B symptoms and the presence of genetic disorder and a negative correlation between leukocyte count and the presence of genetic abnormality. Conclusion: Despite including small number of patients and heterogeneous histological NHL subtypes, our study may provide contribution to the frequency and type of genetic abnormalities in patients with NHL in Turkey. Keywords: Non-Hodgkin lymphoma, genetics, FISH, prognosis
Cite This Article
Bulduk T, Gunduz E, Aras B, Emir B, Isiksoy S. Genetic Abnormalities Detected in Non-Hodgkin Lymphoma. EJMI. 2021; 5(2): 283-288
Corresponding Author: Tuba Bulduk