Factors Affecting Prognosis in Small Cell Lung Cancer
Elanur Karaman1, Arife Ulas2, Serdar Karakullukcu31Department of Medical Oncology, Private Medical Park Karadeniz Hospital, Trabzon, Turkey, 2Department of Medical Oncology, Bursa City Hospital, Bursa, Turkey, 3Department of Public Health, Bayburt Central Community Health Center, Bayburt, Turkey
Objectives: Small-cell lung cancer (SCLC) is the most aggressive type of lung cancer. Despite advances in technology and treatments there is no desirable improvement in survival. The present study evaluated the factors affecting survival in patients with SCLC. Methods: Patients with SCLC followed up in our clinic between 2019 and 2021 were retrospectively reviewed. Univariate and multivariate analyses were performed to identify the prognostic factors. Kaplan-Meier method was used for survival analysis. Results: The 60 patients comprised 50 (83.3%) men and 10 (16.7%) women with a median age of 61 (53.3-67) years. 40 (66.7%) patients were in extensive stage, 13 (21.7%) patients had brain metastases at the time of diagnosis, and 41 (68.3%) patients had extracranial metastases. There were 18(45%) patients with high serum carcinoembryonic antigen levels and 33 (63%) patients with high lactate dehydrogenase levels at the time of diagnosis. Primer disease control control was achieved in 30 (63%) patients, while Progression developed in 26 (45.6%) patients. Median overall survival was 13 months and it was revealed that survival was better in patients who received ?4 cycles of chemotherapy, wholebrain radiotherapy, thoracic radiotherapy and disease control. Conclusion: The success of systemic and local treatment was found to be the most important factor affecting survival in patients with SCLC. Keywords: Small cell lung cancer, brain metastases, prognosis, systemic treatment effect
Cite This Article
Karaman E, Ulas A, Karakullukcu S. Factors Affecting Prognosis in Small Cell Lung Cancer. EJMI. 2021; 5(4): 427-434
Corresponding Author: Elanur Karaman