E-ISSN 2602-3164
EJMI. 2021; 5(2): 189-195 | DOI: 10.14744/ejmi.2021.37729

Effect of Smokıng Status on Hematologıcal Toxıcıtıes and Effectıveness of Fırst-Lıne Platınum Based Chemotherapy Admınıstered to Patıents wıth Non-Small Cell Lung Cancer

Nilay Sengul Samanci1, Emir Celik2, Onur Erk Taparli1, Ezgi Degerli1, Nebi Serkan Demirci1, Fuat Hulusi Demirelli1
1Department of Medical Oncology, Faculity of Cerrahpasa Medicine, Istanbul University, Istanbul, Turkey, 2Department of Internal Medicine, Faculity of Cerrahpasa Medicine, Istanbul University, Istanbul, Turkey

Objectives: In this paper we thus aimed to determine whether smoking during chemotherapy affects the outcome of non-small cell lung cancer (NSCLC) treatment and increases hematological side effects. Method: We have reviewed 70 stage-IV NCSLC patients, who had received chemotherapy as the firstline therapy. Smoking status before and during the administration of the firstline therapy, therapeutic regimens, clinical outcomes, hematological adverse events, and infections that develop during the chemotherapy were investigated. Results: 26 (37.1%) of the patients were former smokers, 44 (62.9%) of the patients were current smokers. 13 (18.6%) patients quit smoking <1 year before, 11 (15.7%) of them stopped smoking <2 weeks before the treatment. 20 (28.6%) of the patients continued to smoke actively during the therapy. No significant differences were found between the smoking groups in terms of neutropenia, anemia, infections that develop during the chemotherapy (p=0.259, p=0.158, p=0.342, respectively). Significant differences were found between the smoking groups in terms of thrombocytopenia and smoking pack-years (p=0.007, p=0.008, respectively). Conclusion: This is the first study evaluating smoking status on hematological toxicities in NSCLC. It should be emphasized however that this study was limited mainly to the patients with stage-IV NSCLC patients, who received palliative treatment. Key Words: Smoking status, hematological toxicities, lung cancer


Cite This Article

Samanci N, Celik E, Taparli O, Degerli E, Demirci N, Demirelli F. Effect of Smokıng Status on Hematologıcal Toxıcıtıes and Effectıveness of Fırst-Lıne Platınum Based Chemotherapy Admınıstered to Patıents wıth Non-Small Cell Lung Cancer. EJMI. 2021; 5(2): 189-195

Corresponding Author: Nilay Sengul Samanci

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