The Significance of Hemogram Parameters for Diagnosis, Prognosis and Treatment of Lung Cancer
Fatma Dindar Celik1, Ceyhun Varim2, Ayse Demirci3, Selcuk Yaylaci2, Ilhan Hacibekiroglu3, Cemil Bilir31Department of Internal Medicine, Sakarya University Faculty of Medicine, Sakarya, Turkey Department of Internal Medicine, Sakarya University Faculty of Medicine, Sakarya, Turkey, 2Department of Internal Medicine, Sakarya University Faculty of Medicine, Sakarya, Turkey, 3Department of Medical Oncology, Sakarya University Faculty of Medicine, Sakarya, Turkey
Objectives: We aimed to investigate the relation between neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR) and platelet/lymphocyte ratio (PLR) with survival and mortality in lung cancer. Methods: 309 patients diagnosed of lung cancer were evaluated in our study. NLR, LMR, PLR were calculated by recording of absolute neutrophil, absolute lymphocyte, absolute monocyte and platelet values from the complete blood count at the time of diagnosis. The cut-off values were determined as 5.28 for NLR, 2.07 for LMR and 150 for PLR by investigating previous studies. Results: The median survival was 13 months, survival was high in adeno carcinoma patients with17 months(median), and low in patients with carcinoid tumors and the tumors whose pathology could not be categorized with 5 months (median), (p<0.05). Overall survival is shorter in patients with high NLR levels and longer high LMR levels (p<0.05 for both). No statistically significant relation was found between survival and PLR level. Conclusion: High NLR and low LMR values were associated with short overall survival but there is no association between PLR level and overall survival. The cut off values specified for NLR and LMR may be beneficial to predict prognosis in patients with lung cancer. Keywords: Lung cancer, neutrophil/lymphocyte ratio, lymphocyte/monocyte ratio, platelet/lymphocyte ratio
Cite This Article
Celik F, Varim C, Demirci A, Yaylaci S, Hacibekiroglu I, Bilir C. The Significance of Hemogram Parameters for Diagnosis, Prognosis and Treatment of Lung Cancer. EJMI. 2021; 5(2): 159-165
Corresponding Author: Ceyhun Varim