Evaluation of Clinical, Laboratory and Treatment Findings of Oncology Patients Diagnosed with COVID-19 Infection
Burcu Yapar Taskoylu1, Tugba Sari2, Atike Gokcen Demiray1, Serkan Degirmencioglu1, Gamze Gokoz Dogu1, Arzu Yaren1, Ahmet Ergin3, Esin Avci4, Canan Karan1, Burcin Cakan Demirel1, Tolga Dogan1, Melek Ozdemir11Department of Medical Oncology, Pamukkale University, Faculty of Medicine, Denizli, Turkey, 2Department of Infectious Diseases and Clinical Microbiology, Pamukkale University Faculty of Medicine, Denizli, Turkey, 3Department of Social Pediatrics, Pamukkale University Faculty of Medicine, Denizli, Turkey, 4Department of Medical Biochemistry, Pamukkale University Faculty of Medicine, Denizli, Turkey
Objectives: The knowledge of the possible differences in the clinical course of COVID-19 infection in cancer patients receiving treatment has not been sufficient to conclude. In this study, we retrospectively evaluated lymphocyte counts, LDH levels, neutrophil/lymphocyte ratios (NLR), platelet lymphocyte ratios (PLR), CRP albumin ratios (CRP/Alb), LDH/ albumin ratios in COVID-19 infected cancer patients actively treated in our clinic. Methods: Cancer patients who were currently under treatment in Department of Medical Oncology, Faculty of Medicine, Pamukkale University during the period between September 2020 and April 2021 were included in the study. During the period, 1363 stage 3-4 patients were received parenteral treatment and 60 patients were diagnosed with COVID-19 infection. Results: The median age of the patients was 60 years (range 19-82 years). Stage of cancer (p=0.028), lymphopenia (p<0.001), elevated LDH (p=0.002), elevated NLR (p<0.001); and elevated LDH/Alb ratios (p<0.001) were identified as the factors affecting mortality. Conclusion: In patients actively under treatment for cancer, clinical course of COVID-19 infection was found to be affected by the stage of the cancer, neutrophil lymphocyte ratios and by LDH/albumin ratios. We think that neutrophil lymphocyte ratios and LDH/albumin ratios are the important prognostic markers in the course of COVID-19 infection in cancer patients. Keywords: Cancer; COVID-19, NLR, LDH/Alb
Cite This Article
Taskoylu B, Sari T, Demiray A, Degirmencioglu S, Dogu G, Yaren A, Ergin A, Avci E, Karan C, Demirel B, Dogan T, Ozdemir M. Evaluation of Clinical, Laboratory and Treatment Findings of Oncology Patients Diagnosed with COVID-19 Infection. EJMI. 2021; 5(4): 417-421
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