Primary Signet-ring Cell Carcinoma of Colorectal Origin: A Poor Prognostic Entity
Abdilkerim Oyman1, Mustafa Basak21Department of Medical Oncology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey, 2Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey
Objectives: In this retrospective study, we aimed to evaluate the clinicopathologic characteristics and survival outcomes of colorectal cancer patients with signet-ring cell component. Methods: 2673 patients diagnosed with colorectal cancer who presented to two different institutions from 2004 to 2019 were investigated. A total of 75 patients with primary signet-ring cell component were included in the study. Results: A total of 75 patients with primary signet-ring cell component were included in the study. 49 (65.3%) were patients with signet-ring cell components more than 50%, 26 (34.7%) were patients with signet-ring cell components less than 50%. At the time of diagnosis, 8 (10.7%) patients had Stage 1-2, 53 (70.7%) patients had Stage 3 and 14 (18.6%) patients had Stage 4 disease. The mean follow-up period of the patients was 54 months. Median overall survival (mOS) was 28.5 months. The mOS of patients who developed metastasis at the time of diagnosis was 9.3 months and mOS of patients without metastasis was 36.5 months. Conclusion: It was observed that primary signet-ring cell carcinomas were mostly seen in males and localized in left colon and had a worse prognosis than classical adenocarcinomas. Keywords: Signet-cell, colorectal adenocarcinoma, survival
Cite This Article
Oyman A, Basak M. Primary Signet-ring Cell Carcinoma of Colorectal Origin: A Poor Prognostic Entity. EJMI. 2021; 5(2): 213-217
Corresponding Author: Abdilkerim Oyman