E-ISSN 2602-3164
EJMI. 2021; 5(1): 16-20 | DOI: 10.14744/ejmi.2021.18888

The Evaluation of the Relationship Between Albuminuria and Serum Asymmetric Dimethyl Arginine Level in Type-2 Diabetes Mellitus

Aysegul Sakin1, Mehmet Selim Aslan2, Ahmet Behlul2, Meltem Gursu3, Namik Yigit2, Egemen Celebi2, Savas Ozturk2
1Department of Internal medicine, University of Health Sciences, Van Training and Research Hospital, Van, Turkey, 2Department of Nephrology, University of Health Sciences, Haseki Training and Research Hospital, Van, Turkey, 3Department of Nephrology, Bezmialem University Faculty of Medicine, Istanbul, Turkey

Objectives: Asymmetrical dimethyl arginine (ADMA) inhibits nitric oxide synthase causing a decline in nitric oxide levels and so endothelial dysfunction. In our study, we analyzed the relationship between albuminuria and ADMA level in type-2 diabetes mellitus (DM). Methods: This is a cross sectional study in which 55 type 2 diabetic patients followed up in diabetes outpatient clinic. Patients were divided into three groups according to albuminuria: normoalbuminuric (Group-1), microalbumiuric (Group-2) and macroalbuminuric (Group-3) patients. ADMA level was measured by ELISA method. Results: A total of 36 (65.45%) patients were female. The median age of patients were 59.9 years. There was no statistically significant difference between groups regarding age, duration of DM, gender, LDL cholesterol and body mass index. The median ADMA level was lower in Group-1 compared to Group-2 and Group-3. ADMA level was significantly correlated with albuminuria. Albuminuria was the only parameter related with ADMA in linear regression analysis. Conclusion: ADMA level is significantly increased even in microalbumiuric stage among patients with type 2 DM. This may show the increased risk of progressive kidney disease in these patients. Keywords: Albuminuria, asymmetrical dimethyl arginine, diabetes mellitus, renal disease


Cite This Article

Sakin A, Aslan M, Behlul A, Gursu M, Yigit N, Celebi E, Ozturk S. The Evaluation of the Relationship Between Albuminuria and Serum Asymmetric Dimethyl Arginine Level in Type-2 Diabetes Mellitus. EJMI. 2021; 5(1): 16-20

Corresponding Author: Aysegul Sakin

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