Association between Beta-Hydroxybutyrate Levels and Survival in Sepsis Patients
Ramazan Acar1, Ismail Erturk1, Gurhan Taskin2, Metin Uyanik3, Ilker Tasci4, Bilgin Bahadir Basgoz4, Serhat Ozer2, Levent Yamanel2, Halil Halil5, Murat Emrah Mavis6, Canan Porucu7, Erdim Sertoglu11Department of Medical Oncology, Unýversity of Health Science, Gulhane Faculty of Medicine, Ankara, Turkey, 2Department of Intensive Care, University of Health Science, Gulhane Faculty of Medicine, Ankara, Turkey, 3Department of Biochemistry, Corlu Government Hospital, Tekirdag, Turkey, 4Department of Internal Medicine, University of Health Science, Gulhane Faculty of Medicine, Ankara, Turkey, 5Department of Urology, Nevsehir Government Hospital, Nevsehir, Turkey, 6Sem Laboratory Devices Marketing Industry and Trade Inc., R&D Center, Istanbul, Turkey, 7Department of Biochemistry, University of Health Science, Gulhane Faculty of Medicine, Ankara, Turkey
Objectives: Sepsis is a systemic inflammatory response. Beta-hydroxybutyrate is a product of ketogenesis that develops after the formation of coenzyme A from fatty acids.We aimed to evaluate the association between survival and beta-hydroxybutyrate in sepsis patients. Methods: This is a single-center, prospective, cross-sectional study. Between May 2018 and May 2019, 51 patients diagnosed with sepsis or septic shock in Gulhane Education and Research Hospital were included in the study. Patients, grouped as non-survivors (Group I) and survivors (Group II) were included in the study and followed for 28 days after their initial blood samples obtained. Plasma beta-hydroxybutyrate level analyses were measured by using Liquid Chromatography Tandem Mass Spectrometry (LC-MS-MS). Results: Within 28 days, 22 patients died (Group I); 29 patients survived (Group II). The SOFA scores were 12.45±4.22 in Group I and 9.97±3.30 (p=0.022) in Group II, and the APACHE-2 scores were 38.05±6.23 in Group I and 34.10±7.22(p=0.046) in Group II. Beta-hydroxybutyrate levels were 20.4 µM (IQR=9.2-29.98 µM) in Group I and 54.9 µM (IQR=13.55–120.83 µM) in Group II (p<0.05). Conclusion: Our study is the first showing the clinical significance of beta-hydroxybutyrate in sepsis patients. Our findings on beta-hydroxybutyrate may illuminate a reasonable positive effect. Keywords: APACHE-2 score, beta-hydroxybutyrate, sepsis, SOFA score
Cite This Article
Acar R, Erturk I, Taskin G, Uyanik M, Tasci I, Basgoz B, Ozer S, Yamanel L, Halil H, Mavis M, Porucu C, Sertoglu E. Association between Beta-Hydroxybutyrate Levels and Survival in Sepsis Patients. EJMI. 2021; 5(1): 39-44
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