The Value of Inflammatory Prognostic Index in Older Patients with Hormone Receptor Positive Metastatic Breast Cancer
Atike Pinar Erdogan1, Ferhat Ekinci1, Ahmet Ozveren2, Senem Yilmaz3, Mustafa Sahin3, Bilgin Demir4, Esin Oktay4, Ahmet Dirican51Department of Internal Medicine Divison of Medical Oncology, Manisa Celal Bayar University Faculty of Medicine, Manisa, Turkey, 2Kent Hospital Oncology Center, İzmir, Turkey, 3Department of Internal Medicine, Manisa Celal Bayar University Faculty of Medicine, Manisa, Turkey, 4Department of Internal Medicine Divison of Medical Oncology, Adnan Menderes University Faculty of Medicine, Aydın, Turkey, 5Department of Medical Oncology, İzmir University of Economics, Medical Park Hospital, İzmir, Turkey
Objectives: To search the prognostic value of an inflammation based prognostic score in older patients with hormone positive, Her2 negative metastatic breast cancer. Methods: A retrospective study of 82 female patients aged 65 years and older with hormon receptor positive, Her-2 negative metastatic breast cancer diagnosed between 2011 and 2018 was conducted with collection of clinical and laboratory data. The inflammatory prognostic index (IPI) was calculated as C-reactive protein × NLR (neutrophil/ lymphocyte ratio)/serum albumin. Survival estimates were calculated with Kaplan-Meier method. Results: The optimal cut-off points of IPI for the stratification of OS was found to be 0,75. Based on this cutoff value, patients were categorized as IPI-high and IPI-low group. High IPI was significantly associated with advanced stage at diagnosis. (p=0.03) The mean OS was 64 months in the IPI-high group and 66.9 months in the IPI-low group. (p=0,813) In patients receiving hormonotherapy in first line treatment PFS was 34.6 months in the IPI-low group and 14.5 months in the IPI high group, and a statistically significant difference was found compared to patients who received chemotherapy in the first line. (p=0,042). Conclusion: Measurement of systemic inflammatory response in older adults with metastatic breast cancer is reliable, available, and can be clinically incorporated into current geriatric oncology algorithms. Keywords: Breast cancer, index, inflammatory, metastatic, older, prognosis
Cite This Article
Erdogan A, Ekinci F, Ozveren A, Yilmaz S, Sahin M, Demir B, Oktay E, Dirican A. The Value of Inflammatory Prognostic Index in Older Patients with Hormone Receptor Positive Metastatic Breast Cancer. EJMI. 2021; 5(4): 515-520
Corresponding Author: Atike Pinar Erdogan