Objectives: Gastric cancer is the fourth most common cancer. Inflammation is a crucial component of tumor progression. Platelet-to-Lymphocyte Ratio (PLR) is a prognostic indicator in many cancer types. Mean Platelet Volume (MPV) is a parameter that reflects platelet function and activity. In this study, we aimed to investigate the prognostic value of Mean Platelet Volume to Lymphocyte Ratio (MPVLR). Methods: Eighty patients who underwent curative resection between January 2014 and December 2018 were included in the study. Clinicopathological parameters and laboratory analyzes of the patients were obtained from computer records retrospectively. MPVLR cut off value was determined via receiver operating characteristic (ROC) curve analysis (low MPVLR: <4.30/high MPVLR: >4.30). MPVLR and clinicopathological characteristics were analyzed by univariate and multivariate analysis. Results: Median survival (OS) was 24 months, and median disease-free survival (DFS) was 16 months. A significant correlation was found between MPVLR and gender (p=0.036), lymphocyte count (p<0.001), PLR (p<0.001) and adjuvant therapy (p=0.004). Median OS was 15 months in the group with high MPVLR, but median survival was not achieved in the group with low MPVLR (p<0.001). Median DFS was 11 months in the high MPVLR group, and median DFS survival was not achieved in the low MPVLR group (p<0.001). In multivariate analysis for DFS, pathological stage (p=0.019) and MPVLR (p=0.005) were detected as independent prognostic factors, whereas multivariate analysis for OS only MPVLR (p=0.003) was determined as independent prognostic factor. Conclusion: Elevated MPVLR is a poor prognostic factor in patients with gastric cancer undergoing curative resection. Our study showed that MPVLR is a more valuable prognostic factor than PLR.Thus, MPVLR could be a novel biomarker for prognostic estimation. Keywords: Gastric cancer,
Corresponding Author: Sahinli H.