E-ISSN 2602-3164
EJMI. 2020; 4(4): 464-470 | DOI: 10.14744/ejmi.2020.62065

Monocyte-to-High Density Lipoprotein Cholesterol Ratio Correlates with the Presence of Cardiovascular Risk Factors in Patients Who Received Upfront Dexrazoxane

Dilek Erdem1, Irem Karaman2
1Department of Internal Medicine, Division of Medical Oncology, Bahcesehir University Faculty of Medicine, Istanbul, Turkey, 2Medical Student (MS), Faculty of Medicine, Bahcesehir University, Istanbul, Turkey

Objectives: In this study, we aimed to retrospectively analyze the baseline characteristics, blood parameters and cardiovascular risk factors of the patients who received dexrazoxane to prevent anthracycline-induced cardiotoxicity. Methods: The data of patients who applied to our hospitalís medical oncology clinic between March 2019 and August 2019, were treated with anthracycline due to various malignancies and received primary prophylaxis with dexrazoxane were retrospectively analyzed. Results: A total of 75 patients included in the study. It was observed that 81.3% (n=61) of the cases had at least one risk factor for developing cardiac side effects. The risk factors of the cases ranged from 0 to 4, with a mean of 1.45. As of August 2019, none of the patients had any symptoms related with cardiac dysfunction A positive correlation between glucose (r=0.234; p=0.044), creatinine (r=0.380; p=0.001), monocyte (r=0.232; p=0.046), triglyceride (r=0.252; p=0.033) measurements of the subjects and the number of risk factors was found. A significant positive correlation analyses was found between the monocyte-to-HDL ratio (MHR) (r=0.233; p=0.048) of the subjects and the number of risk factors. Conclusion: We suggest that dexrazoxane is an important cardioprotective agent that have a huge potential on preventing the long-term cardiotoxicity, and blood parameters especially those which represents the state of inflammation in the body such as MHR should be utilized when assessing the cardiovascular risks of each patient. Keywords: Anthracycline, cardioprotection, cardiotoxicity, cardiovascular risk, dexrazoxane


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Erdem D, Karaman I. Monocyte-to-High Density Lipoprotein Cholesterol Ratio Correlates with the Presence of Cardiovascular Risk Factors in Patients Who Received Upfront Dexrazoxane. EJMI. 2020; 4(4): 464-470

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