How do Functional Tear Tests and Topographical Measurements Change after Topical 0.05% Cyclosporine-A Treatment in Dry-Eye Diagnosed Women?
Esra Sahli1, Cemal Cavdarli11Department of Ophthalmology, Ankara City Hospital, Ankara, Turkey
Objective: To report the effects of cyclosporine-A 0.05% on functional tear tests, corneal thickness and anterior chamber parameters in dry eye (DED) diagnosed women. Material and Methods: Thirty-eyes of 30 women with DED symptoms and Schirmer test scores of ?5 mm/ 5 min with tear break-up-time (BUT) < 10 sec were included. Only the right eyes of the subjects were included. All patients were treated with topical cyclosporine-A 0.05% (b.i.d) and sodium hyaluronate 0.15% (q.i.d). The baseline and 3rd-month results of Schirmer, BUT and topographical central corneal thickness (CCT) and thinnest corneal thickness (TCT), anterior chamber depth (ACD) and volume (ACV) were used for the statistical significance. Results: After topical cyclosporine-A 0.05% treatment, the median of the baseline Schirmer score of 4 mm (range, 0-5) increased to 6 mm (range, 3-5), and the median of the baseline BUT of 3 seconds (range, 1-9) increased to 4.5 seconds (range, 2-13) with a statistical significance. No significant difference was observed on the evaluated parameters of CCT, TCT, ACD, and ACV. Conclusion: Three months' use of topical cyclosporine-A with an artificial tear of topical sodium-hyaluronate has a favorable effect on functional tear tests without any change of corneal and anterior chamber topographical parameters. Keywords: dry eye , cyclosporine , tear test
Cite This Article
Sahli E, Cavdarli C. How do Functional Tear Tests and Topographical Measurements Change after Topical 0.05% Cyclosporine-A Treatment in Dry-Eye Diagnosed Women?. EJMI. 2020; 4(3): 384-389
Corresponding Author: Cemal Cavdarli