E-ISSN 2602-3164
EJMI. 2020; 4(3): 347-352 | DOI: 10.14744/ejmi.2020.39512

General Characteristics and Prognostic Factors on Survival in Neuroendocrine Tumor Patients Diagnosed with Carcinoid Syndrome: Erciyes Multidisiplinary Neuroendocrine Tumor (NET) Group Experience

Ender Dogan1, Mevlude Inanc1, Huseyin Durgun2, Ummuhan Abdulrezzak3, Figen Ozturk4, Erdogan Sozuer5, Gulten Can Sezgin6, Sebnem Gursoy6, Metin Ozkan1, Alper Yurci1, Fahri Bayram2
1Department of Medical Oncology, Erciyes University Faculty of Medicine, Kayseri, Turkey, 2Department of Endocrinology, Erciyes University Faculty of Medicine, Kayseri, Turkey, 3Department of Nuclear Medicine, Erciyes University Faculty of Medicine, Kayseri, Turkey, 4Department of Pathology, Erciyes University Faculty of Medicine, Kayseri, Turkey, 5Department of Surgery, Erciyes University Faculty of Medicine, Kayseri, Turkey, 6Department of Gastroenterology, Erciyes University Faculty of Medicine, Kayseri, Turkey

Objectives: Carcinoid syndrome is one of the functional neuroendocrin tumor symptom. It is a very rare disease and a little known about this syndrome. We aimed a study that evaluating general characteristics and prognostic factors on survival in NET patients diagnosed with carcinoid syndrome. Methods: All patients diagnosed with neuroendocrine tumor were retrospectively reviewed in our institution. The patients diagnosed carsinoid syndrome were included in this study. General characteristics were recorded. Prognostic factors on survival were analysed with Cox regression. Kaplan Meier method was used for overall survival. Results: Among 450 patients diagnosed neuroendocrine tumor in our hospital, 29 of them (6.4%) were presented with carcinoid syndrome. The univariate analysis revealed that age, high tumor grade and ki67 score were correlated with poor overall survival and the multivariate analyses revealed that older age were correlated with poor overall survival. The median OS were 61 months in all grades and 64 months for grade 1 tumors, 45 (13-76) months for grade 2 tumors, 5 months for grade 3 tumors and there were statistically significant difference (p=0.007). Conclusion: Age, grade, ki67 score are important prognostic factor. Age is an independent prognostic factor that affecting survival in carcinoid syndrome patients. Keywords: Carcinoid syndrome, overall survival, predictive factors


Cite This Article

Dogan E, Inanc M, Durgun H, Abdulrezzak U, Ozturk F, Sozuer E, Can Sezgin G, Gursoy S, Ozkan M, Yurci A, Bayram F. General Characteristics and Prognostic Factors on Survival in Neuroendocrine Tumor Patients Diagnosed with Carcinoid Syndrome: Erciyes Multidisiplinary Neuroendocrine Tumor (NET) Group Experience. EJMI. 2020; 4(3): 347-352

Corresponding Author: Ender Dogan

Full Text PDF PDF Download
EJMI & EJMI