Objectives: Natriuretic peptides are proteins secreted by myocardium as a response to the volume and/or pressure load; especially B type Brain Natriuretic Peptide (BNP) has started to be used for the last two decades in issues such as mortality, morbidity after coronary artery surgery and estimation of major adverse cardiac issues, particularly heart failure. The purpose of this study is to research on the activity of BNP in predicting the risk of kidney failure after coronary artery bypass grafting. Material and method: In this study, 40 patients (33 Males/ 7 Females) whose ejection fraction was between %30 and %50 were prospectively examined. These patients were among ones having undergone coronary artery bypass grafting by using a cardiopulmonary machine. Blood was venously taken from patients preoperatively, on the second postoperative day and in the sixth postoperative month in order to examine BUN (blood urea nitrogen), creatinine and plasma NT-proBNP. Results : It was observed that values of NT- proBNP examined preoperatively were negatively correlated with both creatinine clearances before the operation (CrCl pre-op) (p=0.031) and the values of creatinine clearance examined on the second postoperative day (CrCl 2. day) (p=0.014). Discussion: On the basis of our results, we are of the opinion that the preoperative BNP value might be a leading parameter in renal monitoring in the early phase after the operation and in the treatment plan. We need prospective studies with high numbers of patients in this aspect. Key words: Brain natriuretic peptide, acute kidney injury, creatinin clearence, cardiac surgery
Corresponding Author: Mete Gürsoy