Effects of Fenugreek Extract on Total Antioxidant/Oxidant Status at Ehrlich Ascites Tumor Bearing Mice
Mustafa Nisari1, Serife Alpa2, Seher Yilmaz3, Neriman Inanc11Department of Nutrition and Dietetics, Faculty of Health Sciences, University of Nuh Naci Yazgan, Kayseri, Turkey, 2Department of Anatomy, KTO Karatay University Faculty of Medicine, Konya, Turkey, 3Department of Anatomy Bozok University, Faculty of Medicine, Yozgat, Turkey
Objectives: In this study, we aimed to effect of extract that derived from fenugreek on total antioxidant/oxidant status at Ehrlich ascites tumor bearing Balb/C mice. Methods: The phenolic of Fenugreek extract was calculated as gallic acid equivalent using Folin-Ciocalteu method. Fenugreek extract concentration determined 200–400 mg/kg. In the end of in vivo studies, while the weight of experimental animals was estimated. Results: It was found that fenugreek extract delaying the weight gain. Administered fenugreek extract group had lower serum TOS and OSI index and had higher serum TAS compared to the control group. These effects were higher in the group receiving fenugreek 400 mg/kg intraperitoneally. Conclusion: As a result, the fenugreek extract shows antioxidant effect on EAT cells. We believe that our studies will be guiding for new studies about fenugreek and fenugreek could be advised as a food because of its antioxidant effect. Thus, it may have anticancer effect. Keywords: Ehrlich ascites tumor, fenugreek, total antioxidant status, total oxidant status, oxidative stress index
Cite This Article
Nisari M, Alpa S, Yilmaz S, Inanc N. Effects of Fenugreek Extract on Total Antioxidant/Oxidant Status at Ehrlich Ascites Tumor Bearing Mice. EJMI. 2020; 4(1): 116-122
Corresponding Author: Mustafa Nisari